Massive Burns: Retrospective Analysis of Changes in Outcomes Across 18 Years

Completed

• Conditions: Burns

• Registration Number: NCT04480944
• Lead Sponsor: Mette M Berger

Brief Summary

Burns treatment and management has evolved since the 90s, particularly for massive burns (≥ 50% of total body surface area (TBSA)). This study aims at analyzing the impact of the management changes on the length of intensive care unit (ICU) stay, the take of skin grafts and the mortality.

Detailed Description

Review of all massively burned patients treated at Lausanne University Hospital burn intensive care unit (ca. 40-60 patients). Analysis of changes in length of intensive care unit stay (LICU), skin graft take rate or mortality between 2000 and 2018.

Hypothesis : the optimization of resuscitation procedures and of nutrition therapy combined with the use of novel surgical techniques has brought a significant improvement in outcomes.

Association between outcomes and year of admission will be assessed through correlation analysis and logistic regression analysis. Potential cofounders will be assessed through stepwise linear regression analysis

Study Timeline

• Study Start: 2019-01-01
• Primary Completion: 2019-12-31
• Study Completion: 2020-03-31
• Status Verified: 2020-07
• Study First Submitted: 2020-07-17
• Study First Submitted QC: 2020-07-17
• Last Update Submitted: 2020-07-17
• Study First Posted: 2020-07-22
• Last Update Posted: 2020-07-22

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

• All adult patients (>18 years old) with burns ≥50% TBSA admitted in the burn intensive care unit (ICU) of the Lausanne University Hospital

Exclusion Criteria

• Patients admitted in the burn center ICU with another primary diagnosis than burn (e.g. necrotizing fasciitis, gangrene, toxic epidermal necrolysis)
• Patients referred from and/or to another ICU
• Patients in which active withdrawal of care was decided within 48h of admission
• Patients with first degree burns only

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
LICU/Percent TBSA	18 years	Ratio between the length of stay in the ICU and the total body surface area burned

Secondary Outcome Measures

Name	Time	Method
Percent TBSA grafted/ Percent TBSA deep burns	18 years	Ratio between the TBSA grafted and the deep burns TBSA
Daily nutritional intakes	18 years	Daily energy, proteins, lipids and carbohydrates intakes per kilogram of body weight
Mortality	18 years	Percentage of patients who received maximal care and died nonetheless

Trial Locations

Locations (1)

Adult ICU and Burn ICU, Lausanne University Hospital; 🇨🇭 Lausanne, Vaud, Switzerland