ITMCTR2000004124
Not yet recruiting
未知
A clinical study on the prevention and treatment of peripheral neurotoxicity of oxaliplatin by Danggui Sini granule
Jiangsu Province Hospital on Integration Chinese and Western Medicine0 sitesTBD
Overview
- Phase
- 未知
- Intervention
- Not specified
- Conditions
- Not specified
- Sponsor
- Jiangsu Province Hospital on Integration Chinese and Western Medicine
- Status
- Not yet recruiting
- Last Updated
- 3 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •1\. All the selected cases were in accordance with the diagnostic criteria of colorectal cancer and were confirmed by pathology or cytology with stage II\-IV;
- •2\. Karnofsky score above 60, the predicted survival time was more than 4 months;
- •3\. Aged 18\-80 years;
- •4\. No severe damage to the center of gravity, liver, kidney or hematopoietic system;
- •5\. Volunteer to participate in clinical research and sign the informed consent.
Exclusion Criteria
- •1\. with any grade of peripheral neuropathy;
- •2\. Having received chemotherapy drugs with neurotoxicity in one month, such as oxaliplatin, cisplatin, taxanes or vinblastine alkaloids;
- •3\. We are receiving carbamazepine, phenytoin sodium, valproate sodium, gabapentin, pregabalin, venlafaxine, norvenlafaxine, minapram, duloxetine, tricyclic antidepressants and other drugs that may have therapeutic or preventive effects on neuropathy;
- •4\. A history of second or third degree atrioventricular block;
- •5\. Participate in any other clinical study of preventing and treating neurotoxicity;
- •6\. There is a family history of hereditary/familial neuropathy;
- •7\. Patients with severe infection;
- •8\. Patients with mental illness;
- •9\. Pregnant women.
Outcomes
Primary Outcomes
Not specified
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