High dose Rosuvastatin as an adjunctive treatment in acute exacerbation of chronic obstructive pulmonary disease
Phase 2
- Conditions
- Chronic obstructive pulmonary disease with acute exacerbation.Chronic obstructive pulmonary disease with acute exacerbation, unspecified
- Registration Number
- IRCT2016121020024N4
- Lead Sponsor
- Vice chancellor for research, Tehran University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 90
Inclusion Criteria
1) hospitalized patients with acute exacerbation of COPD (AECOPD) according to 2 of following symptoms: Dyspnea, increased sputum and/or purulent sputum;
2) Age > 40;
3)Previous Spirometry or clinical history compatible with COPD.
- Exclusion criteria:
1) Acute coronary syndrome;
2) history of statin therapy;
3)endotracheal intubation;
4) significant associated comorbidities (cardiac, renal or hepatic);
5) history of musculoskeletal disorders;
6) history of intolerance to statins.
Exclusion Criteria
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method In hospital mortality. Timepoint: ?during hospitalization. Method of measurement: monitoring of the patients' clinical status.;Duration of hospitalization. Timepoint: during patients' hospital stay. Method of measurement: time period of hospitalization in days.;Recurrencof acute COPD exacerbation. Timepoint: Within 3 months after taking meication. Method of measurement: Telephone follow-up.
- Secondary Outcome Measures
Name Time Method COPD Assessment Test (CAT) questionnaire, persian version. Timepoint: in 1st and 3rd day after initiation of medication. Method of measurement: COPD Assessment Test (CAT) questionnaire score.;Arterial oxygen saturation of hemoglobin. Timepoint: in 1st and 3rd day of taking medication. Method of measurement: Pulse oximeter - Beurer GmbH.;Arterial PCO2. Timepoint: in 1st and 3rd day of taking medication. Method of measurement: VL 995 blood gas analyzer.