To evaluate upshayatmaka effect of Rasnadidashmool kwath in disintegration of etiopathogenesis of Amavata
试验速览
- 阶段
- 3 期
- 状态
- 尚未招募
- 发起方
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Improvement in DAS-28 Score
研究概览
简要总结
Amavata (rheumatoid arthritis) is one of the dreaded disease that mankind facing day by day. It not only affects the social and economic position of individual and his family but also leads to draining of national resource due to the work hours lost, resulting in diminished production. Amavata (RA) is reported to be 1-2% of general population with male and female ratio 3:1.
Rasanadidahmool kwath mentioned in Chakradutta in Amavata rogadhikara which have the properties of Amahar, Shothahar, and Shoolhar. and Erandadi kwath as comprative arm mentioned in Bhashajya Ratnavali has also shows the same property. The primary aim of this research is to find out potency of both drug in Amavata (RA) and which one is better.
Asssesment criteria- 1- Objective parameters like CRP, RA-factor, ESR and other will be assessed before and after treatment.
**2-**Subjective improvement will be assessed by adopting suitable scoring method.
Study type- Randomized comparative clinical trial
Study time- 24 months
Intervention time- 35 days
Sample size- 100 (50 in each group)
Group-A- The trial drug Rasnadidashmool kwath 48gm BD
Group-B- The comparative drug Erandadi kwath 48 gm BD
研究设计
- 研究类型
- Interventional
- 分配方式
- Computer generated randomization
- 盲法
- Not Applicable
入排标准
- 年龄范围
- 18.00 Year(s) 至 65.00 Year(s)（—）
- 性别
- All
入选标准
- •1-Amavata of any dosha Anubandha 2-Diagnosis of Amavata as per symptoms described in Madhav Nidana 3-Diagnosis of Rheumatoid arthritis as per ACR criteria.
排除标准
- •1-Pregnant women and lactating mother 2-Patients of RA with know case of rheumatic fever juvenile RA, Ankylosing spondylitis 3-Patients of RA with complications like deformity 4-Any other disorder with Amavata.
结局指标
主要结局
Improvement in DAS-28 Score
时间窗: 35 days
Symptomatic relief in cardinal signs and symptoms of patients
时间窗: 35 days
次要结局
- Subjective improvement in the patients will be assessed by adopting suitable scoring pattern.(Decrease in elevated levels of CRP,ESR,RA factor and other biochemical parameters.)