Effects of Transcranial Direct Current Stimulation on Hemiplegic Upper Extremity Function After Strokes
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Stroke
- Sponsor
- Chonbuk National University Hospital
- Enrollment
- 72
- Locations
- 1
- Primary Endpoint
- Fugl-Meyer Upper Motor Score change
- Last Updated
- 9 years ago
Overview
Brief Summary
The investigators hypothesize that transcranial direct current stimulation (tDCS) can improve upper limb motor recovery in the sub-acute phase of stroke patients.
This is a randomized, controlled, double blind, cross-over, multicentre, clinical trial.
Detailed Description
The investigators hypothesize that transcranial direct current stimulation (tDCS) can improve upper limb motor recovery in the sub-acute phase of stroke patients. This is a randomized, controlled, double blind, cross-over, multicentre, clinical trial. Informed consent was obtained from all participants and procedures were conducted according to the Declaration of Helsinki. The protocol was approved by the Chonbuk National Uni. Hospital IRB, KOREA. Seventy-two stroke patients in the sub-acute phase will be recruited in three centers of neurorehabilitation in republic of Korea. Patients will be randomly divided to four groups; group1 is anodal stimulation on the lesioned primary motor cortex, group 2 is cathodal stimulation on the non-lesioned primary motor cortex, group 3 is dual stimulation such as anodal stimulation on the lesioned side and cathod stimulation on the non-lesioned side, and group 4 is shame stimulation group. The stimulation will be conducted 2mA for 20 minute a day, 5 days per weeks, totally 2 weeks. Fugl-Meyer upper motor score will be measured as a primary outcome.
Investigators
Myoung Hwan Ko
Professor
Chonbuk National University Hospital
Eligibility Criteria
Inclusion Criteria
- •Unilateral Stroke patients
- •Inclusion must be in the sub-acute phase defined as within 48hr-4 weeks after stroke
- •Patients who have evoked motor potentials on the first dorsal interossei muscles on hemiplegic hand
- •The patient has subscribed the informed consent
Exclusion Criteria
- •Insert a metal object on the head
- •Convulsive disorders
- •History of brain diseases other than stroke
Outcomes
Primary Outcomes
Fugl-Meyer Upper Motor Score change
Time Frame: before treatment, 48 hours after treatment, 4 weeks after treatment
Secondary Outcomes
- Range of Motion (ROM) change(before treatment, 48 hours after treatment, 4 weeks after treatment)
- Korean version Modified Bathel Index (KMBI) change(before treatment, 48 hours after treatment, 4 weeks after treatment)
- Manual Muscle Test (MMT) change(before treatment, 48 hours after treatment, 4 weeks after treatment)