Effects of Transcranial Direct Current Stimulation Associated With Physical Therapy on Motor Rehabilitation in Parkinson´s Disease Patients
Overview
- Phase
- Phase 2
- Intervention
- Not specified
- Conditions
- Parkinson Disease
- Sponsor
- Universidade Federal de Pernambuco
- Enrollment
- 12
- Locations
- 1
- Primary Endpoint
- Change From Unified Parkinson´s Disease Rating Scale - UPDRS
- Status
- Completed
- Last Updated
- 10 years ago
Overview
Brief Summary
The present study aims to investigate the effect of transcranial direct current stimulation (tDCS) associated with physiotherapy in parkinson´s rehabilitation. Previous studies showed that tDCS could reduce the bradykinesia, one of the symptom of Parkinson disease. In this way, this study will combine tDCS with physiotherapy in order to enhance the motor rehabilitation and the quality of life.
Detailed Description
12 patients were participated of this study.After screening to check the eligibility criteria and giving informed consent, they were randomized in two groups. All patients were submitted to a 10 therapeutic sessions that occurred 3 times per week. Before, immediately after and 1 month after the last session patients were submitted to an evaluation with the follow tests: Unified Parkinson´s Disease Rating Scale(UPDRS), Jebsen Taylor Test (JTT) and Parkinson's Disease Quality of Life (PDQL). Furthermore, before and after each session the patients were submitted to transcranial magnetic stimulation (TMS) to evaluate cortical excitability through motor threshold and motor evoked potential. In experimental sessions, the subjects always received physiotherapy with conventional techniques, the protocol followed the clinical practice guideline for physical therapy in Parkinson disease with the Royal Dutch Society Therapy. During tDCS protocol the patients seated in a comfortable chair with head and arm rests. Continuous current was applied using a pair of saline-soaked surface sponge electrodes (surface 35 cm2), the anode electrode was placed over the primary motor cortex and cathode above contralateral orbit. tDCS was applied of twice stimulation of 13 minutes with 20 minutes of interval between them and a current strength of 1mA. Sham tDCS was applied by current flow of 30s.
Investigators
Kátia Monte-Silva
Doctor
Universidade Federal de Pernambuco
Eligibility Criteria
Inclusion Criteria
- •Parkinson disease comproved by a neurologist Regular treatment with dopamine or other drugs against parkinson -
Exclusion Criteria
- •pregnant history of convulsion metal implant in the region of skull or face change in medication during the study realize other physical therapy in the same time of the study previous surgery for parkinson disease
Outcomes
Primary Outcomes
Change From Unified Parkinson´s Disease Rating Scale - UPDRS
Time Frame: At baseline, after 1 month
Unified Parkinson´s Disease Rating Scale is the sum of 27 questions, total score ranging from108 (best possible outcome) to 0 (worst possible outcome)", as accurate and appropriate
Secondary Outcomes
- Change From Cortical Excitability Via Single Transcranial Magnetic Stimulation(per sesssion: at baseline and after physical therapy)