Intraoperative Brain Microdialysis to Assess Neuroinflammation in Epileptic Tissue Immediately Prior to Surgical Resection.
概览
- 阶段
- 不适用
- 干预措施
- Intraoperative brain microdialysis
- 疾病 / 适应症
- Epilepsy
- 发起方
- Mayo Clinic
- 入组人数
- 3
- 试验地点
- 2
- 主要终点
- Detection of analytes/protein
- 状态
- 撤回
- 最后更新
- 26天前
概览
简要总结
This research study will investigate the fluid from the area of the brain that is being removed during clinical epilepsy surgery. The goal is to analyze this fluid for inflammatory markers that can potentially help identify new strategies in the future to control seizures in individuals with epilepsy who fail to respond to currently available drugs.
研究者
入排标准
入选标准
- •Failure to respond to at least two trials of anti-seizure drugs with different mechanisms of action
- •Normal MRI
排除标准
- •Active immunomodulatory therapy
- •Autoimmune disorder
- •Signs or symptoms consistent with comorbid infection
- •Oncological comorbidity
研究组 & 干预措施
drug-resistant temporal lobe epilepsy
Our current standard practice is to use a lateral approach through the middle temporal gyrus to place 3 depth electrodes targeting the hippocampus for intraoperative verification of pathological epileptiform activity prior to resection. Our research protocol will add one FDA approved electrode that has a central cannula for insertion of a microdialysis probe. The electro-physiological data that will be gathered is not altered and this methodology will not impact standard clinical care, except and will not to extend the duration in the OR - the measurements will occur during the clinical electrocorticography (ECoG; intracranial electroencephalography (iEEG)) procedure by 15 min.
干预措施: Intraoperative brain microdialysis
结局指标
主要结局
Detection of analytes/protein
时间窗: Through study completion, up to 5 years
Presence of protein in the microdialysate