Prevalence and Long Term Effects of Frailty in Elderly Intensive Care Patients
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Frailty
- Sponsor
- University Hospital of North Norway
- Enrollment
- 300
- Locations
- 5
- Primary Endpoint
- EuroQol 5-Dimension 5-Level (EQ-5D-5L)
- Status
- Recruiting
- Last Updated
- 2 years ago
Overview
Brief Summary
The primary aim is to study change of critical frailty scale (CFS) and health related quality of life (EQ-5D-5L) in a long-term follow-up of ICU survivors. We aim to identify important ICU related predictors for change in CFS and EQ-5D-5L in long term follow up (1 yr).
Secondary aim is to investigate how CFS pre-admission is related to intrahospital treatment intensity level, severity score and mortality.
Detailed Description
This is a multi-centre norwegian observational, prospective multicenter Norway coordinated from University hospital North Norway, Tromso. The study is approved by The Regional Committee for Medical Research Ethics Northern Norway. The following scores will be assessed by asking the patient and relative during ICU stay: CFS, EQ5DL before current critical illness. The following demographic and clinical data will be retrieved from the medical records: Comorbidity before critical illness, reasons for ICU admission, daily severity score (SOFA- score), length of mechanical ventilation, dialysis, tracheostomy, Habitat before and after ICU treatment, ICU and hospital length of stay, complications retrieved during intensive care treatment, mortality, limitation of treatment. The patients will be followed up with telephone interview after hospital discharge for evaluation of: Comorbidity, CFS, EQ5DData for all sites are collected and managed using RedCap electronic data capture tools. Three research nurses will do the follow up with telephone interviews on all sites and record the data in RedCap. We aim to enroll 300 patients before 31. Des 2024.
Investigators
Eligibility Criteria
Inclusion Criteria
- •\>= 65 years
- •≥ 24 hours mechanical ventilation
- •Written informed consent from patient or next of kin
Exclusion Criteria
- •Readmission of patient included in the study
- •Not possible to obtain a valid CFS or and EQ-5D-5L at admission or follow-up of CFS because of social context or language.
Outcomes
Primary Outcomes
EuroQol 5-Dimension 5-Level (EQ-5D-5L)
Time Frame: Change in EQ-5D-5L from 3 months to 12 months
The scale measures quality of life on a 5-component scale
Mortality
Time Frame: ICU-stay or subsequent 12 months.
Mortality during ICU-stay or subsequent 12 months.
Change in Clinical frailty score
Time Frame: Change in Clinical Frailty score from 3 months to 12 months follow up
Score from 1 to 9.
Secondary Outcomes
- ICU readmission(Long-term follow up (1 yr))
- ICU-LOS(Through total ICU stay, up to 3 months)
- Treatment intensity level(From inclusion in the study to discharge from intensive care unit, up to three months.)