Frailty: Prevalence and Response to Left Ventricular Assist Device Therapy in Older Heart Failure Patients

Thomas Jefferson University1 site in 1 country20 target enrollmentMay 2014

ConditionsSystolic Heart Failure

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Systolic Heart Failure
Sponsor: Thomas Jefferson University
Enrollment: 20
Locations: 1
Primary Endpoint: Change in frailty following left ventricular assist device implantation
Status: Completed
Last Updated: 8 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

This is an observational study evaluating changes in frailty and associated impairments in older heart failure patients receiving left ventricular assist device therapy.

Registry

clinicaltrials.gov

Start Date

May 2014

End Date

July 2017

Last Updated

8 years ago

Study Type

Observational

Sex

All

Investigators

Sponsor

Thomas Jefferson University

Responsible Party

Sponsor

Eligibility Criteria

Inclusion Criteria

•60 years old or older
•Scheduled to undergo left ventricular assist device implantation at Thomas Jefferson University

Exclusion Criteria

•Unable or unwilling to provide informed consent
•Unable to complete baseline frailty assessment

Outcomes

Primary Outcomes

Change in frailty following left ventricular assist device implantation

Time Frame: Baseline (prior to surgery); 10 days, 1 month, 3 months, and 6 months post-operatively

Frailty will be assess based on the domains initially described by Fried and colleagues: weakness, low physical activity, unintentional weight loss, slowness and exhaustion. Additional frailty measures include the Short Physical Performance Battery (SPPB), as well as gait speed and hand grip strength as single item measures.