Frailty, Cognitive Function and Health-related Quality of Life in Older Adults With Advanced Chronic Kidney Disease: Mortality and Dialysis Initiation, a Prospective Cohort Study.

Grigore T. Popa University of Medicine and Pharmacy1 site in 1 country240 target enrollmentMarch 1, 2019

Overview

This observational study explores the impact of cognitive impairment and frailty in older adults with advanced chronic kidney disease ].

The main question[s] it aims to answer are:

What determines the time to initiate dialysis? Cognitive impairment or frailty?
What does predict the time to death? Presence of frailty or cognitive impairment?
What does correlate strongly with time-low health-related quality of life? frailty or cognitive impairment?

Registry

clinicaltrials.gov

Start Date

March 1, 2019

End Date

March 12, 2023

Last Updated

2 years ago

Study Type

Observational

Sex

All

Sponsor

Grigore T. Popa University of Medicine and Pharmacy

Responsible Party

Principal Investigator

Hani Hussien

Doctor

Grigore T. Popa University of Medicine and Pharmacy

•Patients age 65 years or older.
•CKD stage 4 and 5 who were identified by two consecutive measurements of estimated glomerular filtration rate (eGFR) \<30 mL/min/1.73 m2 separated by more than 3 months.

•Patients younger than 65 years old.
•Chronic kidney disease stages 1,2, and
•Dialysis dependence
•History of kidney transplantation.
•Initial visit with the health care provider.
•Recent acute kidney injury.
•Patients who had been hospitalized for more than 2 months before the visit (because long hospitalization might affect the degree of frailty)
•Patients with myocardial infarction and cerebrovascular accident 3 months before the assessment
•Patients who are blind or with limb amputation.
•Patients who refuse to participate.