Frontotemporal Dementia Risk Cohort (FTD-RisC): Early biomarker abnormalities in patients with frontotemporal dementia - FTD-RisC study

Erasmus MC, Universitair Medisch Centrum Rotterdam0 个研究点目标入组 250 人开始时间: 待定最近更新: 2024年6月24日

适应症

试验速览

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•1) Patients with frontotemporal dementia referred to our referral center and diagnosed with use of International Consensus Criteria. The dementia symptoms have to be mild (clinical dementia rating <=1). Inclusion will be made when age of onset of dementia is below 65 year. Patients with all variants of frontotemporal dementia (behavioural frontotemporal dementia, semantic dementia, progressive non-fluent aphasia) will be included.
•2) Patients with mild Alzheimer dementia diagnosed according to International Consensus Criteria. The dementia has to be mild (clinical dementia rating <=1). Inclusion will be made when age of onset of dementia is below 65 year.
•3) Asymptomatic, first degree relatives of dementia patients due to genetic mutations. They have 50% chance of having the mutation and developing FTD. For the current study we collect new DNA and we will test them for the genetic mutation but keep them uninformed on the result unless they want to be informed. Participation is possible from 18 years and over.
•4) Healthy persons who are age matched with persons having frontotemporal dementia.

•1) Patients with moderate to severe dementia (clinical dementia rating > 1).
•2) Persons with a previous stroke or other (neurological) conditions that may affect cognitive functions (brain tumour, multiple sclerosis, use of psycho-active medications).
•3) Contra-indication for undergoing MRI (pacemaker or other metal implants, claustrophobia, or unability to lie still for a period of 30 minutes in the MRI scanner).

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