NL-OMON49263
Recruiting
Not Applicable
Frontotemporal dementia Imaging of Neuroinflammation, Degeneration and Microglia-Related Effects - FIND-MORE
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Frontotemporal dementia
- Sponsor
- Erasmus MC, Universitair Medisch Centrum Rotterdam
- Enrollment
- 32
- Status
- Recruiting
- Last Updated
- 2 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •\- Able to tolerate the \[18F]DPA\-714 PET\-MRI scan procedures and to make an
- •informed decision to participate in this study
- •\- Symptomatic patients must meet clinical criteria for FTD clinical syndromes
- •\- Presymptomatic individuals and healthy controls must show no objective
- •evidence of cognitive impairment
Exclusion Criteria
- •\- Has contraindications for MRI scanning, e.g. metal objects in the body,
- •claustrophobia
- •\- Has evidence of structural brain abnormalities that are likely to interfere
- •with the interpretation of PET scan
- •\- Has one or more comorbidities that may interfere with the outcomes of the
- •study (e.g. significant immune disease, neurological disease, CNS malignancy)
- •\- Has a history of moderate or severe traumatic brain injury
- •\- Has made use of immunomodulatory or immunosuppressive therapy in the 3 months
- •prior to the scan
- •\- Has any disease or uses medication that may compromise the function of the
Outcomes
Primary Outcomes
Not specified
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