Effects of a Short-term Aerobic Interval Exercise Program on Cardiac Fat and Function in Women With Obesity: A Pilot Study

Not Applicable

Withdrawn

• Conditions: Obesity
• Interventions: Other: Aerobic Interval Training

• Registration Number: NCT04802005
• Lead Sponsor: Southern Illinois University Edwardsville

Brief Summary

The overall goal of this project is to the study the effects of an aerobic interval training program on cardiac fat, and its relationship to cardiac function using cardiac Magnetic Resonance Imaging.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2021-03-13
• Study First Submitted QC: 2021-03-13
• Study Start: 2021-03-16
• Study First Posted: 2021-03-17
• Primary Completion: 2021-04-16
• Study Completion: 2021-04-16
• Status Verified: 2021-09
• Last Update Submitted: 2021-09-20
• Last Update Posted: 2021-09-21

Recruitment & Eligibility

• Status: WITHDRAWN
• Sex: Female
• Target Recruitment: Not specified

Inclusion Criteria

• females, age 18-40 years old, body mass index (BMI) ≥ 30 kg/m2 and < 39.9 kg/m2, without known metabolic and/or cardiovascular disease

Exclusion Criteria

• known CV, metabolic or pulmonary diseases or conditions, muscular-skeletal injuries (i.e. spine, knees, hips or shoulders, taking medications that affect endocrine or cardiovascular function, hypertension, being engaged in moderate intensity exercise more than two times per week or moderate-high intensity training of any type and frequency, being pregnant, cigarette smoking, having non-removable pieces or devices incompatible with DXA and CMR assessment

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Aerobic interval	Aerobic Interval Training	Aerobic interval will consist of a supervised aerobic interval training sessions 3 times/week. Duration will range between 45-50 min/session depending on the exercise energy expenditure (target expenditure \~450-500kcal/session). Each interval will have a total duration of 5 min, and it will be divided into 2 periods. The first period will consist of 3 minutes of high-intensity activity at 70-85% of predicted HRmax, and for the second period the intensity will be reduced to 60-65% of predicted HRmax for 2 minutes. The training sessions will be carried out outdoors at the trails located on campus. The activity will consist of walking and/or light jogging. The speed/incline will be changed depending on the participants' heart rate and perception using the Borg's rating of perceived exertion (RPE) as needed. The RPE for the first period range will be 13-17 (15-17 at the end of the period) and 10-12 for the second period.

Primary Outcome Measures

Name	Time	Method
Changes in Cardiac Function	2 assessment points: at baseline and week 5	Cardiac Function will be measured using cardiac Magnetic Resonance
Changes in Cardiac Adipose Tissue (CAT)	2 assessment points: at baseline and week 5	CAT will be measured using cardiac Magnetic Resonance

Secondary Outcome Measures

Name	Time	Method
Changes in Body Composition	2 assessment points: at baseline and week 5	Body composition will be measured using dual-energy x-ray absorptiometry
Changes in Blood Pressure	2 assessment points: at baseline and week 5	Blood pressure will be measured using pulse wave analysis
Changes in Cardiorespiratory Function	2 assessment points: at baseline and week 5	Cardiorespiratory Function will be measured on a treadmill with a metabolic cart
Changes in Muscular Strength	2 assessment points: at baseline and week 5	Muscular Strength will be assessed through 1 repetition maximum (1RM).

Trial Locations

Locations (1)

Southern Illinois University Edwardsville; 🇺🇸 Edwardsville, Illinois, United States