Blood Gas and Bleeding Disorders in Healthy Volunteers Exposed to Nitroglycerin and Nitrogen Compounds of Blasting Gelatin: a Field Report During a Cave Accident
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 94
- 试验地点
- 1
- 主要终点
- Change from baseline haemostasis analysis at 2 hours
研究概览
简要总结
The aim of the study was to investigate the possible relationship about blood gas and bleeding disorders in healthy volunteers of blasters and no blasters groups of the Italian National Mountain and Cave Rescue who handled nitrogen compounds and nitroglycerine and then they were exposed to combustion products from an accidental uncontrolled detonation of micro-charges during a cave unblocking procedure.
详细描述
This was a field report of clinical data collected during an accidental uncontrolled detonation of micro-charges, while the cave unblocking procedure was performed by volunteers of blaster group and non blasters group of the Italian National Mountain and Cave Rescue, in a cave in Trieste (Italy; altitude entrance: 348 meters above sea level; total length: 413,5 meters; total depth of 307 meters).
Before going into the cave (Time 0), the following clinical data were collected: age, sex, body mass index; smoke (yes/no), heart rate, arterial blood pressure (mean arterial pressure), oxygen saturation measured with pulse oxymetry, epitympanic temperature, blood gases analyses and the haemostasis measures.
After the accidental uncontrolled detonation of micro-charges, (Time 1) heart rate, arterial blood pressure, oxygen saturation measured with pulse oxymetry, epitympanic temperature, blood gases analyses and the haemostasis measures were recorded in each volunteers.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Other
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy volunteers of Italian National Mountain and Cave Rescue
排除标准
- •gas exchange disorders
- •quantitative abnormalities of coagulation assessment
- •qualitative abnormalities of coagulation assessment
结局指标
主要结局
Change from baseline haemostasis analysis at 2 hours
时间窗: 10 minutes before going in to the cave and two hours after the volunteers come out from the cave
Under aseptic conditions, a venipuncture was performed: three mL of blood sample were used for the haemostasis measure, by using Rotational Thromboelastometry
Change from baseline arterial blood gases analysis at 2 hours
时间窗: 10 minutes before going in to the cave and two hours after the volunteers come out from the cave
Under aseptic conditions, a puncture of radial artery was performed: one mL was tested for the blood gases analysis, by using i-STAT analyser.
次要结局
- Change from baseline arterial blood pressure at 2 hours(10 minutes before going in to the cave and two hours after the volunteers come out from the cave)
- Change from baseline pulse oxymetry at 2 hours(10 minutes before going in to the cave and two hours after the volunteers come out from the cave)
- Change from Baseline heart rate at 2 hours(10 minutes before going in to the cave and two hours after the volunteers come out from the cave)
- Change from baseline epitympanic temperature at 2 hours(10 minutes before going in to the cave and two hours after the volunteers come out from the cave)
研究者
Emiliano Petrucci
Principal Investigator
San Salvatore Hospital of L'Aquila