Salivary Alpha Amylase as a Biomarker of Transdermal Vagus Nerve Stimulation
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 100
- 试验地点
- 2
- 主要终点
- Change in Salivary Alpha Amylase concentration.
研究概览
简要总结
The proposed project tests the hypothesis that salivary alpha amylase concentration is a reliable biomarker of the effect of transdermal vagus nerve stimulation (tVNS) in humans.
详细描述
The study examines the capacity of tVNS to alter the concentrations of salivary alpha amylase. Changes in salivary alpha amylase concentrations reflect alteration of CNS structures anatomically linked to the vagus, thus alertation of alpha amylase would indicate the efficacy of tVNS. This study is intended to study basic mechanisms and is not directed toward the treatment of any disease state. Particapants taking part in the study will spend about one hour in a single session.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy individuals
排除标准
- 未提供
结局指标
主要结局
Change in Salivary Alpha Amylase concentration.
时间窗: Within single one hour session change in concentration immediately prior to and following stimulation and 5 minutes post-stimulation
Biomarker of autonomic arousal level
次要结局
- Change in Heart Rate Variability.(Within single one hour session change in heart rate variability immediately prior to and following stimulation period.)
研究者
Rodney Roosevelt
Assistant Professor
Arkansas Tech University