Salivary Alpha Amylase as a Biomarker of Transdermal Vagus Nerve Stimulation
- Conditions
- No Condition Salivary Alpha Amylase
- Registration Number
- NCT03854539
- Lead Sponsor
- Arkansas Tech University
- Brief Summary
The proposed project tests the hypothesis that salivary alpha amylase concentration is a reliable biomarker of the effect of transdermal vagus nerve stimulation (tVNS) in humans.
- Detailed Description
The study examines the capacity of tVNS to alter the concentrations of salivary alpha amylase. Changes in salivary alpha amylase concentrations reflect alteration of CNS structures anatomically linked to the vagus, thus alertation of alpha amylase would indicate the efficacy of tVNS. This study is intended to study basic mechanisms and is not directed toward the treatment of any disease state. Particapants taking part in the study will spend about one hour in a single session.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 100
- Healthy individuals
- NA
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method Change in Salivary Alpha Amylase concentration. Within single one hour session change in concentration immediately prior to and following stimulation and 5 minutes post-stimulation Biomarker of autonomic arousal level
- Secondary Outcome Measures
Name Time Method Change in Heart Rate Variability. Within single one hour session change in heart rate variability immediately prior to and following stimulation period. Change in beat to beat interval.
Related Research Topics
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Trial Locations
- Locations (1)
Arkansas Tech University
🇺🇸Russellville, Arkansas, United States
Arkansas Tech University🇺🇸Russellville, Arkansas, United States