Measuring Cortisol Levels in Persons With Parkinson's (PD)
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 131
- 试验地点
- 2
- 主要终点
- Awakening Salivary Cortisol level (ug/dL) Response
研究概览
简要总结
The objective of this study is to evaluate the cortisol awakening response with persons with Parkinsons Disease (PD), Huntingtons Disease (HD), and controls. These data are desired so experience can be gained with measuring stress levels subjectively and objectively in persons with PD, HD, and controls.
详细描述
Telephone consent will be obtained.
Participants will collect saliva at twelve time points - four times a day for three days.
Visits will be conducted virtually (over the internet).
The virtual visit is to assess Parkinson's or Huntington's disease status, stress, mood, and quality of life.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 99 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Group (3) Inclusion:
- •No significant neurological disorder
- •PSS score of greater than or equal to
- •Group (5) Inclusion:
- •HD diagnosis or HD gene carrier
- •a Perceived Stress Scale (PSS) score higher than or equal to
- •Group (6) Inclusion:
- •HD diagnosis or HD gene carrier
- •PSS score lower than 13
- •Group (7) Inclusion:
- •PD diagnosis
- •Prior completion of the study.
排除标准
- •The use of medications known to effect cortisol levels (estrogen, synthetic glucocorticoids, androgens, phenytoin, spironolactone, prednisone, prednisolone, and hydrocortisone).
结局指标
主要结局
Awakening Salivary Cortisol level (ug/dL) Response
时间窗: Collected upon awakening and 30 minutes after awakening
Salivary Cortisol level (ug/dL) Response is the change in cortisol between awakening and 30 minutes after awakening.
次要结局
未报告次要终点
研究者
Amie Hiller, MD
Neurologist
Oregon Health and Science University