Onderzoek naar het effect van de toevoeging van D-cycloserine aan exposure sessies bij de behandeling van patiënten met een obsessieve-compulsieve stoornis.
Recruiting
- Conditions
- Obsessive-compulsive disorder(NLD: Obsessieve-compulsieve stoornis).
- Registration Number
- NL-OMON27916
- Lead Sponsor
- Meerkanten GGZErmelo
- Brief Summary
/A
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 40
Inclusion Criteria
1. Patients with a primary DSM-IV diagnosis of OCD with an age of 18 years and older as established with the Structural Clinical Interview for axis I DSM-IV Disorders (SCID I);
2. Obsessive-compulsive complaints has to be such that exposure in vivo is feasible at the outpatient department, in the clinic or the direct environment;
Exclusion Criteria
1. Addiction to alcohol or drugs or abuse of these compounds;
2. A primary diagnosis of a personality disorder;
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The differences in scores on the Y-BOCS (clinical interview) between baseline and half-way and afterwards the series of ERP sessions will be taken as the primary outcome measure. The mean scores of the two groups (placebo vs. DCS) at these time points will be compared and analyzed. One and three months after the scheduled ERP sessions, when patients may have received further regular CBT, the Y-BOCS will be done again and it can be determined if acceleration of effect results in better outcome at follow up.
- Secondary Outcome Measures
Name Time Method 1. Assessments of the rate of anxiety and avoidance related to specific target symptoms;<br /><br>2. CGI and the PADUA-R;<br /><br>3. Response percentages (defined as minimal 30% reduction on the Y-BOCS) will be compared.