Attenuation of the Hemodynamic Response to Double-lumen Endotracheal Intubation With Nebulized Lidocaine
- Registration Number
- NCT05850702
- Lead Sponsor
- RenJi Hospital
- Brief Summary
The goal of this clinical trial is to test the effect of nebulized lidocaine on the hemodynamic response in the participant undergoing double-lumen endotracheal intubation.
The main question it aims to answer is to evaluate the changes in mean arterial pressure after intubation.
Participants will inhale 5ml of 2% lidocaine by nebulization15min before intubation.
Researchers will compare saline group to see if saline effects
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- NOT_YET_RECRUITING
- Sex
- All
- Target Recruitment
- 92
Inclusion Criteria
- aged 18-65 years, American Society of Anesthesiologists class I-II
- participants undergoing double-lumen endotracheal intubation under general anesthesia
- signed informed consent and volunteered to participate in the experiment
Exclusion Criteria
- Poor control of hypertension
- preoperative arrhythmia
- severe coronary artery or heart valve disease
- sequelae of cerebrovascular accident
- severe lung, liver, kidney and immune system diseases
- Suspected difficult airway
- confirmed or suspected allergy to this trial drug
- As judged by the investigator to be ineligible for the study, such as communication impairment (language or intelligence)
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description saline Saline control group lidocaine Lidocaine Intervention group
- Primary Outcome Measures
Name Time Method mean arterial pressure after intubation Immediately after intubation
- Secondary Outcome Measures
Name Time Method