Bolus Administration of Intravenous Lidocaine at the Time of Abdominal Hysterectomy
- Registration Number
- NCT03748108
- Lead Sponsor
- Aswan University Hospital
- Brief Summary
The objective of the study to evaluate whether a bolus administration of intravenous lidocaine decreases postoperative pain and represents an opioid-minimizing strategy after abdominal hysterectomy compared with placebo.
- Detailed Description
Total abdominal hysterectomy (TAH) is the most common gynecological operation worldwide. Some studies noticed about abused of opioids in postoperative care, led to a more adverse effect of opioids, slow recovery, prolong the length of hospitalized stay and consequently increase the unnecessary cost of treatment.
Guidelines have considered using preoperative analgesics for reducing post-operative opioids consumption, including lidocaine infusion. With its anti-inflammatory, anti-hyperalgesia and analgesic properties, intravenous perioperative lidocaine infusion (IVLI) has been used for optimal postoperative care in different surgeries and in various procedures involving hysterectomy.
Therefore, the aim of this study is to assess the efficacy of bolus administration of intravenous lidocaine at the time of abdominal hysterectomy to decrease postoperative pain and reducing morphine requirements, after TAH.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- 120
- Women ranging age between 35-60 years a who undergoing elective total abdominal hysterectomy
- Participants had known sensitivity to lidocaine
- Participants had difficulty in intubation
- Participants were on chronic pain medication or already on long-term opioids
- Participants smokers
- Participants with disabilities who were unable to communicate pain levels
- refuse to consent
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Placebo Placebo A bolus intravenous dose of a saline placebo over 15 s just before the induction of general anesthesia. lidocaine lidocaine A bolus intravenous dose of 1.5 mg/kg lidocaine 2% over 15 s just before the induction of general anesthesia.
- Primary Outcome Measures
Name Time Method Visual analog score during movement 30 minutes postoperative movement-evoked pain measurements ranging from 0 to 10, where 0 no pain and 10 maximum pain
- Secondary Outcome Measures
Name Time Method Visual analog score during rest 24 hours post operative ranging from 0 to 10, where 0 no pain and 10
number of patients need Fentanyl consumption 24 hours post operative number of patients need Fentanyl consumption
number of days patients stay in hospital 4 weeks calculation of number of days patients stay in hospital
Trial Locations
- Locations (1)
Aswan University
🇪🇬Aswan, Egypt