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Lidocaine

Generic Name
Lidocaine
Brand Names
Agoneaze, Akten, Alivio, Anestacon, Anodyne Lpt, Astero, Band-aid Hurt-free, Cathejell, Curacaine, Depo-medrol With Lidocaine, Dermacinrx Lido V Pak, Dermacinrx Phn Pak, Dermacinrx Prikaan, Diphen, Emla, Fortacin, Glydo, Instillagel, Kenalog, Lido Bdk, Lido-prilo Caine Pack, Lidocan, Lidodan, Lidoderm, Lidopac, Lidopril, Lidopro, Lidosol, Lidothol, Lidotral, Lignospan, Marcaine, Max-freeze, Medi-derm With Lidocaine, Neo-bex, Octocaine, Octocaine With Epinephrine, Oraqix, P-care, P-care X, Pliaglis, Prilolid, Prizotral, Procomycin, Readysharp Anesthetics Plus Ketorolac, Readysharp-A, Readysharp-p40, Readysharp-p80, Relador, Synera, Triple Antibiotic, Venipuncture Px1, Viadur, Xylocaine, Xylocaine With Epinephrine, Xylocard, Xylonor, Zingo, Ztlido
Drug Type
Small Molecule
Chemical Formula
C14H22N2O
CAS Number
137-58-6
Unique Ingredient Identifier
98PI200987

Overview

Ever since its discovery and availability for sale and use in the late 1940s, lidocaine has become an exceptionally commonly used medication . In particular, lidocaine's principal mode of action in acting as a local anesthetic that numbs the sensations of tissues means the agent is indicated for facilitating local anesthesia for a large variety of surgical procedures . It ultimately elicits its numbing activity by blocking sodium channels so that the neurons of local tissues that have the medication applied on are transiently incapable of signaling the brain regarding sensations . In doing so, however, it can block or decrease muscle contractile, resulting in effects like vasodilation, hypotension, and irregular heart rate, among others . As a result, lidocaine is also considered a class Ib anti-arrhythmic agent . Nevertheless, lidocaine's local anesthetic action sees its use in many medical situations or circumstances that may benefit from its action, including the treatment of premature ejaculation . Regardless, lidocaine is currently available as a relatively non-expensive generic medication that is written for in millions of prescriptions internationally on a yearly basis. It is even included in the World Health Organization's List of Essential Medicines .

Background

Ever since its discovery and availability for sale and use in the late 1940s, lidocaine has become an exceptionally commonly used medication . In particular, lidocaine's principal mode of action in acting as a local anesthetic that numbs the sensations of tissues means the agent is indicated for facilitating local anesthesia for a large variety of surgical procedures . It ultimately elicits its numbing activity by blocking sodium channels so that the neurons of local tissues that have the medication applied on are transiently incapable of signaling the brain regarding sensations . In doing so, however, it can block or decrease muscle contractile, resulting in effects like vasodilation, hypotension, and irregular heart rate, among others . As a result, lidocaine is also considered a class Ib anti-arrhythmic agent . Nevertheless, lidocaine's local anesthetic action sees its use in many medical situations or circumstances that may benefit from its action, including the treatment of premature ejaculation . Regardless, lidocaine is currently available as a relatively non-expensive generic medication that is written for in millions of prescriptions internationally on a yearly basis. It is even included in the World Health Organization's List of Essential Medicines .

Indication

Lidocaine is an anesthetic of the amide group indicated for production of local or regional anesthesia by infiltration techniques such as percutaneous injection and intravenous regional anesthesia by peripheral nerve block techniques such as brachial plexus and intercostal and by central neural techniques such as lumbar and caudal epidural blocks .

Associated Conditions

  • Acute Otitis Media (AOM)
  • Anorectal discomfort
  • Arrhythmia
  • Back Pain Lower Back
  • Bacterial Vaginosis (BV)
  • Burns
  • Cervical Syndrome
  • Earache
  • Fissure;Anal
  • Haemorrhoids
  • Infection
  • Inflammatory Reaction caused by ear infection-not otherwise specified
  • Insect Bites
  • Joint Pain
  • Mixed Vaginal Infections
  • Multiple Myeloma (MM)
  • Myringitis
  • Neuritis
  • Osteolysis caused by Bone Tumors
  • Osteoporosis
  • Otitis Externa
  • Pain caused by ear infection-not otherwise specified
  • Pain, Inflammatory
  • Postherpetic Neuralgia
  • Primary Hyperparathyroidism (PHPT)
  • Rheumatic Diseases
  • Rheumatic Joint Disease
  • Sciatica
  • Skin Irritation
  • Soft Tissue Inflammation
  • Sore Throat
  • Sunburn
  • Susceptible infections
  • Trichomonas Vaginitis
  • Ulcers, Leg
  • Urethral Strictures
  • Ventricular Arrhythmia
  • Vulvovaginal Candidiasis
  • Abrasions
  • Anal discomfort
  • Cutaneous lesions
  • Gum pain
  • Minor burns
  • Superficial Wounds
  • Susceptible Bacterial Infections
  • Ulceration of the mouth
  • Viral infections of the external ear canal

FDA Approved Products

Lidocaine
Manufacturer:medsource pharmaceuticals
Route:TOPICAL
Strength:5 g in 100 g
Approved: 2018/12/20
NDC:45865-911
Lidocaine Viscous
Manufacturer:A-S Medication Solutions
Route:ORAL, TOPICAL
Strength:20 mg in 1 mL
Approved: 2022/08/08
NDC:50090-6186
Lidocaine
Manufacturer:St. Mary's Medical Park Pharmacy
Route:TOPICAL
Strength:50 mg in 1 g
Approved: 2023/05/15
NDC:60760-201
Lidocaine
Manufacturer:AVKARE
Route:TOPICAL
Strength:50 mg in 1 g
Approved: 2023/12/08
NDC:42291-495
Lidocaine
Manufacturer:Proficient Rx LP
Route:TOPICAL
Strength:50 mg in 1 g
Approved: 2023/06/01
NDC:71205-814

Singapore Approved Products

Vagisil Medicated Creme
Manufacturer:Laleham Health and Beauty Limited
Form:CREAM
Strength:2% w/w
Online:Yes
Approved: 1998/12/03
Approval:SIN10494P
XYLOTIN 50 - Lidocaine Hydrochloride INJECTION USP 50MG/5ML
Manufacturer:Aspiro Pharma Limited
Form:INJECTION, SOLUTION
Strength:50mg/5ml
Online:Yes
Approved: 2020/06/12
Approval:SIN15952P
LIGNOCAINE INJECTION 2% (Without preservative)
Manufacturer:PFIZER (PERTH) PTY LTD
Form:INJECTION
Strength:20 mg/ml
Online:Yes
Approved: 1991/04/08
Approval:SIN05673P
DENTINOX TEETHING GEL
Manufacturer:Dendron Brands Ltd
Form:GEL
Strength:0.33% w/w
Online:Yes
Approved: 1990/03/28
Approval:SIN04042P
LYDOCAN INJECTION 2%
Manufacturer:Y.S.P. Industries (M) Sdn. Bhd.
Form:INJECTION, SOLUTION
Strength:200mg/10ml
Online:Yes
Approved: 2018/08/01
Approval:SIN15519P

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