Efficacy of Postoperative Pain Control Between Transarticular VS Periartiucular Multimodal Drug Infiltration in Total Hip Arthroplasty: Double-blinded Randomized Control Trial

Not Applicable

Completed

• Conditions: Pain, Post Operative; Arthroplasty Complications
• Interventions: Procedure: transarticular multimodal drug infiltration

• Registration Number: NCT05325671
• Lead Sponsor: Rajavithi Hospital

Brief Summary

This research aim to improve postoperative outcome in total hip arthroplasty(THA) by using local mixture infiltration as bupivacaine + NSAID + epinephrine + tranxemic acid. In the present time these mixture components has shown to improve THA outcome by aspect of postoperative pain control, postoperative opioid consumption, postoperative bleeding, LOS and postoperative rehabilitation without increasing complication but the accuracy of infiltration technique which gives the best outcome has not been yet discovered.Recently study by Hashimoto et al has risen that these technique can be administrated by both periarticular and intra-articular approach.By considering the complexity of human anatomy around the hip tissue we assume that the intra-articular(transarticular) may given equivalence (may be better) outcome with lowering procedural related complication comparing to periarticular infiltration approach.

Detailed Description

Not available

Study Timeline

• Status Verified: 2022-04
• Study Start: 2022-04-05
• Study First Submitted: 2022-04-05
• Study First Submitted QC: 2022-04-05
• Study First Posted: 2022-04-13
• Primary Completion: 2023-09-30
• Study Completion: 2023-10-31
• Last Update Submitted: 2024-01-24
• Last Update Posted: 2024-01-25

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 120

Inclusion Criteria

• patient who would go on cemented and cementless THA
• age 45-60 years of age
• voluntary decision exclusion criteria
• bilateral THA
• revision surgery
• history of pelvic and hip surgery previously
• allergy to medication in protocol
• CKD stage 4-5, chronic liver disease with Child Pugh B or C
• pregnancy
• history of hip injection
• U/D
• hypercoagulable state
• abnormal laboratory coagulation study as INR > 1.4 or aPTT > 1.4
• abnormal platelet function
• thrombocytopenia
• PE , DVT, ischemic stroke, CAD/ischemic heart disease
• use of anticoagulant or hormonal usage
• anesthesia by general anesthesia or additional nerve block
• can not understand PCA usage
• use postopertive wound drainage

Exclusion Criteria

Not provided

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
transarticular multimodal drug infiltration	transarticular multimodal drug infiltration	infiltration the mixture into intraarticular by catheter guided approach
periarticular multimodal drug infiltration	transarticular multimodal drug infiltration	3 location of infiltration 1. hip capsule 2. gluteus medius and short external rotator 3. gluteus maximus

Primary Outcome Measures

Name	Time	Method
Visual analogue scale at rest on postoperative day1st and 2nd	1 week

Secondary Outcome Measures

Name	Time	Method
total morphine consumption in whole postoperative period	1 week
total morphine consumption in first 24 hours postoperative period via PCA pump	1 week
length of stay	1 week
postoperative complication	1 week

Trial Locations

Locations (1)

Rajavithi Hospital; 🇹🇭 Bangkok, Thailand