Prospective Evaluation of the Clinical Utility of Ketamine in Pain Desensitisation in Chronic Pai

• Conditions: Multiple Sclerosis; Complex Regional Pain Syndrome; Anaesthesiology - Pain management; Neurological - Multiple sclerosis

• Registration Number: ACTRN12613000022763
• Lead Sponsor: Monash University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2013-01-08
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: ot yet recruiting
• Sex: Female
• Target Recruitment: 60

Inclusion Criteria

Negative pregnancy test at start of experiment
Female
Multiple Sclerosis or Complex Regional Pain Syndrome

Exclusion Criteria

Allergy to ketamine
History of moderate-to-severe brain injury, alcohol abuse.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Pain sensitivity in response to mechanical (von Frey filaments), thermal (hot plate), and pressure stimuli (odometer).<br><br>[One week prior to Burst Ketamine treatment (i.e. baseline), and at one, three, six, and twelve weeks post-treatment]

Secondary Outcome Measures

Name	Time	Method
Pen-and-paper questionnaires and tests designed to assess:<br>Mood & Anxiety (HADS, DASS-42) <br>Sleep Quality (Epworth scale and PSQI) <br>Cognition (RAVLT, Rey's Complex Figure Test, TMT etc.)<br>[One week prior to the Burst Ketamine” treatment (i.e. baseline), and at one, three, six, and twelve weeks post-treatment.]