Wheeze in preschool children: the predictive value of episodic viral wheeze and multiple-trigger wheeze in the development of childhood asthma

• Conditions: preschool wheezing, asthma

• Registration Number: NL-OMON25868
• Lead Sponsor: Amphia Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 28 February 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 171

Inclusion Criteria

6- to 9-year old children who were known for recurrent wheezing at the age of 1- to 4- years, treated by hospital-based pediatricians and included in our previous (WHEEP)study. Recurrent wheezing was defined as a minimum of 3 reported episodes in the year before inclusion, of which at least one must have been confirmed by a pediatrician.Children were then recruited from pediatric departments of ten general and academic hospitals in the Netherlands. During the 1-year (WHEEP)study period wheeze patterns were classified from patient diaries and compared to pediatrician assigned phenotypes

Exclusion Criteria

No new exclusion criteria. As in the former (WHEEP)study, children of whom their parents do not understand the Dutch language are not eligible.

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The predictive value of the phenotypes episodic viral wheeze and multiple trigger wheeze (clinical as well as diary-based) in the development of asthma

Secondary Outcome Measures

Name	Time	Method
The occurrence of viral upper respiratory infections at preschool age and the risk of developing asthma, and differences in microbiome at preschool age between children who develop childhood asthma and children who do not.