Phenotypes of Preschool Wheezing Among Children Attending Sohag University Hospital

Recruiting

• Conditions: Wheezing
• Interventions: Radiation: Chest x- Rays

• Registration Number: NCT06603584
• Lead Sponsor: Sohag University

Brief Summary

Wheezing in preschool children is very common, with a wide differential diagnosis. It is essential to be sure of the exact sound that parents are describing; the term 'wheeze' is often applied to non-specific sound.Approximately one-third of children are diagnosed with wheeze in the first 3 years of life, making wheeze one of the commonest respiratory symptoms.The differential diagnosis of wheeze is wide, and different management strategies are needed depending on the underlying phenotype. The word 'wheeze' is used to describe many different sounds. That can be heard by both clincians and parent. Even if true wheeze is heard, this should not be automatically assumed to be due to bronchospasm. Airway narrowing by mucus will produce true wheeze but does not respond to bronchodilators. Similarly, airway malacia, either related to intrinsic airway wall defects or loss of alveolar tethering points, are also causes of bronchodilatorunresponsive wheeze; indeed, bronchodilators, by reducing airway smooth muscle tone, may actually worsen airway narrowing.

Detailed Description

Not available

Study Timeline

• Study Start: 2024-06-04
• Status Verified: 2024-09
• Study First Submitted: 2024-09-17
• Study First Submitted QC: 2024-09-17
• Last Update Submitted: 2024-09-17
• Study First Posted: 2024-09-19
• Last Update Posted: 2024-09-19
• Primary Completion: 2025-04-04
• Study Completion: 2025-04-04

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

• patients from the age of one to five years with recurrent wheezing

Exclusion Criteria

• Children above 5 years and below one year old.
• Failure to obtain informed consent.
• Children below 6 years with chest diseases other than wheezing

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
group A	Chest x- Rays	Bronchial Asthma
group B	Chest x- Rays	Chronic Aspiration
group C	Chest x- Rays	Primary Ciliary Dyskinesia
group D	Chest x- Rays	Cystic Fibrosis

Primary Outcome Measures

Name	Time	Method
Forced Expiratory Volume	6 months	Changes in Forced Expiratory Volume in bronchial Asthmatic Patient

Trial Locations

Locations (1)

Sohag university Hospital; 🇪🇬 Sohag, Egypt