跳至主要内容
临床试验/NCT01345812
NCT01345812
终止
4 期

Time-lapse Assessed Evaluation of Embryo Development After Stimulation With Either Recombinant Follicle Stimulating Hormone (FSH) or Urine-derived Follicle Stimulating Hormone (FSH).

University of Aarhus1 个研究点 分布在 1 个国家目标入组 291 人2011年4月

概览

阶段
4 期
干预措施
HP-HMG
疾病 / 适应症
Patients for In Vitro Fertilization(IVF)Treatment
发起方
University of Aarhus
入组人数
291
试验地点
1
主要终点
Number of Top Quality Embryos day 2
状态
终止
最后更新
13年前

概览

简要总结

The primary purpose of the investigation is to identify differences in embryo development after follicle stimulation with two different gonadotrophins.

详细描述

So far the assessment of the development potential of the single embryo has been limited by the vulnerability of the embryos when exposed to fluctuations in temperature and CO2 levels. Thus embryos can only be allowed to leave incubators for a very limited time period. However, with the development of time-lapse systems for clinical use it is possible to make continuous time-lapse recordings of embryos while they are in a safe incubator environment. The embryos are not compromised, but the entire embryonic development can still be seen, and will subsequently provide new and essential information on the competence of the single embryo. Based on the above it is expected that the probability of selecting the most viable and competent embryo is increased, which, in turn, will increase the success rate for couples seeking infertility treatment.

注册库
clinicaltrials.gov
开始日期
2011年4月
结束日期
2012年8月
最后更新
13年前
研究类型
Interventional
研究设计
Parallel
性别
All

研究者

责任方
Sponsor

入排标准

入选标准

  • Participants(heterosexuals, lesbian couples and single women) must sign a document of informed consent
  • Female age 21-45 years(both inclusive)
  • Patients for IVF treatment
  • Regular menstrual cycle 21-35 days(both inclusive)
  • Normal FSH levels(1-15 IU/L)
  • BMI between 18-32(both inclusive)
  • Patients must be able to read and understand patient information in national language

排除标准

  • Endometriosis as primary diagnosis

研究组 & 干预措施

urine-derived FSH

Follicle stimulating hormone

干预措施: HP-HMG

recombinant FSH

Follicle stimulation hormone

干预措施: recombinant FSH

结局指标

主要结局

Number of Top Quality Embryos day 2

时间窗: 44 h after insemination

The oocytes are inseminated and loaded to the time-lapse instrument and cultured for two days. The embryo developemnt are followed at the movie and the embryos are scored according to a standard scoring criteria at 44 h after insemination

次要结局

  • Implantation rate(5 weeks after embryo transfer)

研究点 (1)

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