Time-lapse Assessed Evaluation of Embryo Development After Stimulation With Either Recombinant Follicle Stimulating Hormone (FSH) or Urine-derived Follicle Stimulating Hormone (FSH).
Overview
- Phase
- Phase 4
- Intervention
- HP-HMG
- Conditions
- Patients for In Vitro Fertilization(IVF)Treatment
- Sponsor
- University of Aarhus
- Enrollment
- 291
- Locations
- 1
- Primary Endpoint
- Number of Top Quality Embryos day 2
- Status
- Terminated
- Last Updated
- 13 years ago
Overview
Brief Summary
The primary purpose of the investigation is to identify differences in embryo development after follicle stimulation with two different gonadotrophins.
Detailed Description
So far the assessment of the development potential of the single embryo has been limited by the vulnerability of the embryos when exposed to fluctuations in temperature and CO2 levels. Thus embryos can only be allowed to leave incubators for a very limited time period. However, with the development of time-lapse systems for clinical use it is possible to make continuous time-lapse recordings of embryos while they are in a safe incubator environment. The embryos are not compromised, but the entire embryonic development can still be seen, and will subsequently provide new and essential information on the competence of the single embryo. Based on the above it is expected that the probability of selecting the most viable and competent embryo is increased, which, in turn, will increase the success rate for couples seeking infertility treatment.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Participants(heterosexuals, lesbian couples and single women) must sign a document of informed consent
- •Female age 21-45 years(both inclusive)
- •Patients for IVF treatment
- •Regular menstrual cycle 21-35 days(both inclusive)
- •Normal FSH levels(1-15 IU/L)
- •BMI between 18-32(both inclusive)
- •Patients must be able to read and understand patient information in national language
Exclusion Criteria
- •Endometriosis as primary diagnosis
Arms & Interventions
urine-derived FSH
Follicle stimulating hormone
Intervention: HP-HMG
recombinant FSH
Follicle stimulation hormone
Intervention: recombinant FSH
Outcomes
Primary Outcomes
Number of Top Quality Embryos day 2
Time Frame: 44 h after insemination
The oocytes are inseminated and loaded to the time-lapse instrument and cultured for two days. The embryo developemnt are followed at the movie and the embryos are scored according to a standard scoring criteria at 44 h after insemination
Secondary Outcomes
- Implantation rate(5 weeks after embryo transfer)