Time-lapse Assessed Evaluation of Embryo Development After Stimulation With Either Recombinant Follicle Stimulating Hormone (FSH) or Urine-derived Follicle Stimulating Hormone (FSH).
概览
- 阶段
- 4 期
- 干预措施
- HP-HMG
- 疾病 / 适应症
- Patients for In Vitro Fertilization(IVF)Treatment
- 发起方
- University of Aarhus
- 入组人数
- 291
- 试验地点
- 1
- 主要终点
- Number of Top Quality Embryos day 2
- 状态
- 终止
- 最后更新
- 13年前
概览
简要总结
The primary purpose of the investigation is to identify differences in embryo development after follicle stimulation with two different gonadotrophins.
详细描述
So far the assessment of the development potential of the single embryo has been limited by the vulnerability of the embryos when exposed to fluctuations in temperature and CO2 levels. Thus embryos can only be allowed to leave incubators for a very limited time period. However, with the development of time-lapse systems for clinical use it is possible to make continuous time-lapse recordings of embryos while they are in a safe incubator environment. The embryos are not compromised, but the entire embryonic development can still be seen, and will subsequently provide new and essential information on the competence of the single embryo. Based on the above it is expected that the probability of selecting the most viable and competent embryo is increased, which, in turn, will increase the success rate for couples seeking infertility treatment.
研究者
入排标准
入选标准
- •Participants(heterosexuals, lesbian couples and single women) must sign a document of informed consent
- •Female age 21-45 years(both inclusive)
- •Patients for IVF treatment
- •Regular menstrual cycle 21-35 days(both inclusive)
- •Normal FSH levels(1-15 IU/L)
- •BMI between 18-32(both inclusive)
- •Patients must be able to read and understand patient information in national language
排除标准
- •Endometriosis as primary diagnosis
研究组 & 干预措施
urine-derived FSH
Follicle stimulating hormone
干预措施: HP-HMG
recombinant FSH
Follicle stimulation hormone
干预措施: recombinant FSH
结局指标
主要结局
Number of Top Quality Embryos day 2
时间窗: 44 h after insemination
The oocytes are inseminated and loaded to the time-lapse instrument and cultured for two days. The embryo developemnt are followed at the movie and the embryos are scored according to a standard scoring criteria at 44 h after insemination
次要结局
- Implantation rate(5 weeks after embryo transfer)