Study the effect of drug on awakening time of patient and its quality after completion of surgery
Not Applicable
Completed
- Conditions
- Health Condition 1: null- cholithiasis for laparoscopic cholesystectomy
- Registration Number
- CTRI/2018/05/013679
- Lead Sponsor
- SGRDIMSAR
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 100
Inclusion Criteria
ASA physical status I and II
Either sex
Scheduled for laparoscopic cholecystectomy under GA
Exclusion Criteria
ASA III and above
Major hepatic, renal or cardiovascular dysfunction
Pregnancy
Hypersensitivity to aminophylline or other methylxanthines
Chronic therapy with aminophylline or other methylxanthines (to avoid toxic drug levels).
Uncontrolled hypertension and myocardial disease
Patient on following drugs- Macrolides, Calcium channel blockers, Cimetidine, Quinolones, Rifampicin, Carbamazepine, Lithium, Phenytoin.
Chronic smokers
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To evaluate the effect of aminophylline and placebo on BIS scores in patients under isoflurane anaesthesia and to correlate it with clinical recovery charcteristics. <br/ ><br>To compare the effect of aminophylline vs placebo on clinical recovery characteristics in patients undergoing laparoscopic cholecystectomy under isoflurane anaesthesia <br/ ><br>Timepoint: clinical recovery charcteristics and heminodynaminc varibles at removal of laparoscpe and every minute thereafter till extubation.
- Secondary Outcome Measures
Name Time Method intraoperative and postoperative hemodymaic stability and postoerative cognitive effect on patientTimepoint: intraoperative and upto 24 hour after surgery