Effects of implementation of KDIGO guidelines controlled by biomarkers in cardiac surgery on incidence and severity of acute kidney injury

Not Applicable

• Conditions: OPS-2013: 5-361 (bypass surgery)OPS-2013: 5-35 (cardiac valve and septum surgery); N17; Acute renal failure

• Registration Number: DRKS00006139
• Lead Sponsor: niversitätsklinikum MünsterKlinik für Anästhesiologie, operative Intensivmedizin und Schmerztherapie

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2014-07-03
• Study Completion: 2015-03-10
• Results First Posted: 2017-01-27
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 281

Inclusion Criteria

1. Cardiac surgery
2. (TIMP-2) * (IGBP7)-urine concentration>=0,3
3. Informed consent

Exclusion Criteria

1. Patients with pre-existing kidney disease not requiring RRT (GFT < 30mL/min)
2. patients with pre-existing RRT
3. patients with a (glomerulo)nephritis, interstitial nephritis or vasculitis
4. pregnancy
5. patients after kidney transplantation

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Incidence of acute kidney injury in the first three postoperative days

Secondary Outcome Measures

Name	Time	Method
- severity of AKI<br>- renal recovery (also GFR and creatinine levels at discharge and after 30, 60 and 90 days)<br>- mortality after 30, 60 and 90 days<br>- ICU and hospital stay<br>- MAKE (major adverse kidney events) after 30, 60 and 90 days<br>- biomarkers at the beginning (randomization) and 12 h postoperative<br>