Implementation of the KDIGO guidelines for the prevention of AKI in patients after cardiac surgery – an international multicenter observational trial

• Conditions: N17; Acute renal failure

• Registration Number: DRKS00024204
• Lead Sponsor: Department of Anesthesiology, Intensive Care and Pain Medicine, University Hospital Münster

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2021-01-29
• Study Completion: 2021-12-26
• Results First Posted: 2023-06-01
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 537

Inclusion Criteria

1. Adult patients undergoing cardiac surgery with CPB
2. Age between 18-90 years
3. Written informed consent

Exclusion Criteria

1. Preexisting AKI (stage 1 and higher)
2. Patients with cardiac assist devices (ECMO, LVAD, RVAD, IABP)
3. Pregnancy, breastfeeding
4. Known (Glomerulo-) Nephritis, interstitial nephritis or vasculitis
5. Chronic kidney disease (CKD) with eGFR < 20 ml/min/1.73m2
6. Dialysis dependent CKD
7. Prior kidney transplant within the last 12 months
8. Persons held in an institution by legal or official order
9. Persons with any kind of dependency on the investigator or employees by the investigator

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To assess the adherence to the preventive care bundle according to the KDIGO guidelines in patients undergoing cardiac surgery with cardiopulmonary bypass

Secondary Outcome Measures

Name	Time	Method
- occurrence of AKI within 72 hours after cardiac surgery<br>- severity stage of AKI within 72 hours after cardiac surgery<br>- use and duration of renal replacement therapy (RRT)<br>- length of ICU stay<br>- length of hospital stay<br>- MAKE30 (combined endpoint consisting of persistent renal dysfunction (defined as serum creatinine = 1.5-times baseline), RRT and mortality) at day 30)