Growth Hormone Deficiency and Empty Sella Cardio-Metabolic Risk Factors in Obesity: a Cross-Sectional Study
Completed
- Conditions
- Obesity
- Registration Number
- NCT02092779
- Lead Sponsor
- University of Roma La Sapienza
- Brief Summary
Obesity is a disease not always attributable to nutritional imbalance, frequently associated with changes in key hypothalamic-pituitary (HP) axes. The regain of weight loss after hypochaloric diets has been ascribed to these HP disregulations. The aim of the study is to explore pituitary morphology and its association with pituitary function and metabolic phenotype in outpatient obese individuals evaluated in the period 2010-2013 at the Department of Experimental Medicine of the University of Rome La Sapienza, with features of HP disease in a cross-sectional .
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 447
Inclusion Criteria
- Adult obese
Exclusion Criteria
- psychiatric disturbances, pregnancy, lactation, or drugs known to affect pituitary function
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Cranio-caudal pituitary diameter in millimeters Participants will be followed for the duration of day hospital stay, an expected average of 1 week
- Secondary Outcome Measures
Name Time Method Growth hormone releasing hormone plus arginine test for GH secretion μg/L Participants will be followed for the duration of day hospital stay, an expected average of 1 week