The Role of microbial produced ethanol in etiology of Non-Alcoholic Steatohepatitis (ETHANASH trial)

Completed

• Conditions: fatty liver disease; Non-alcoholic fatty liver disease; 10017969

• Registration Number: NL-OMON48065
• Lead Sponsor: Academisch Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 28 February 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 20

Inclusion Criteria

- Diagnosis of NASH on liver biopsy taken on clinical grounds at the outpatient
clinic
- 18-65 years of age
- BMI > 25 kg/m2
- Subjects should be able to give informed consent,

Healthy controls:
- BMI >25 kg/m2
- 18-65 years of age
- Subjects should be able to give informed consent

Exclusion Criteria

- Primary lipid disorder
- Known genetic basis for insulin resistance or glucose intolerance
- Ethanol intake
- Pregnancy, females who are breastfeeding
- Hepatitis B and/or C
- Auto-immune hepatitis
- Wilson disease/ alpha 1-antitripsine deficiency
- Hemochromatosis
- Use of drugs interacting with Fomepizole (products requiring CYP2E1 for
metabolizing).
- Use of drugs interacting with Clindamycine, metronidazole or ciprofloxacin.

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified