The Role of microbial produced ethanol in etiology of non-alcoholic steatohepatitis
Completed
- Conditions
- ASH
- Registration Number
- NL-OMON20655
- Lead Sponsor
- Amsterdam UMC, locatie AMC
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 20
Inclusion Criteria
Diagnosis of NASH on liver biopsy taken on clinical grounds at the outpatient clinic, or healthy volunteer
-18-65 years of age
-BMI > 25 kg/m2
-Subjects should be able to give informed consent
Exclusion Criteria
-Primary lipid disorder
-Known genetic basis for insulin resistance or glucose intolerance
-Ethanol intake > 2 U/week
-Pregnancy, females who are breastfeeding
-Hepatitis B and/or C
-Liver cirrhosis
-Auto-immune hepatitis
-Wilson disease3/ alpha 1-antitripsine deficiency
-Hemochromatosis
-Use of drugs interacting with fomepizole (products requiring CYP2E1 for metabolizing).
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To investigate whether microbial produced ethanol plays a role in the development of NASH.
- Secondary Outcome Measures
Name Time Method