Comparison of the effect of endotracheal suction using two methods, endotracheal N-acetylcysteine and normal saline, on hemodynamic parameters and arterial blood gases in intubated patients under mechanical

Phase 3

Recruiting

• Conditions: Patients should be intubated and under mechanical ventilation..; Dependence on respirator [ventilator] status; Z99.11

• Registration Number: IRCT20231104059949N1
• Lead Sponsor: Zabol University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 22 January 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 90

Inclusion Criteria

Patients who are connected to mechanical ventilation for at least 48 hours and at most one week
Patients with endotracheal tubes
Patients who are between 20 and 60 years old
Patients who are hemodynamically stable (heart rate between 60-100 beats per minute, blood pressure between 160/100-110/60 mmHg, Spo2 more than 90%, urinary output more than 30 ml/hour)
Patients with normal electrolyte levels and no cardiac arrhythmia
Insensitivity to N-acetylcysteine and other drugs
Absence of pulmonary edema, chronic obstructive pulmonary diseases and asthma
Patients who do not have chest trauma or chest tube
Absence of brain edema, spinal cord injury, increased intracranial pressure

Exclusion Criteria

Patients who are hemodynamically unstable (heart rate less than 60 beats per minute, blood pressure less than 100/60 mmHg, Spo2 less than 90%)
Any changes in mechanical ventilation settings during the study
Death of the patient
Lack of consent of the patient's family
Use of muscle relaxants and inotropic drugs during the study

Study & Design

• Study Type: interventional
• Study Design: Not specified