A prospective trial to study the trend of markers of cerebral of cerebral oxygenation and metabolism in patients undergoing clipping of cerebral aneurysm under total intravenous anaesthetic techniques and inhalational anaesthetic technique
Not Applicable
- Conditions
- Health Condition 1: O- Medical and Surgical
- Registration Number
- CTRI/2023/06/053493
- Lead Sponsor
- ISNACC
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
ASA class I- IV (class IV due to SAH)
-Both gender
-Age 18-65 years, undergoing clipping of cerebral aneurysm in the neurosurgery operation theatre.
-informed consent from patient or legal heir
Exclusion Criteria
-ASA class III,IV (due to other systemic comorbidities), V
-Age < 18 years, > 65 years
-Severe or uncompensated cardiovascular, renal, hepatic or endocrine disease
-Pregnancy, postpartum, lactating females
-Drug allergy to Propofol or Fentanyl
-Refusal to consent by patient or legal heir
-Patients who are intubated and on mechanical ventilation
-Emergency surgery
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1.To compare changes in the lactate oxygen index in patients undergoing clipping of cerebral aneurysm under propofol-based total intravenous anaesthesia and sevoflurane based inhalational anesthesia <br/ ><br>2.To compare the changes in the jugular venous oxygen saturation in patients undergoing clipping of cerebral aneurysm under propofol based intravenous anesthesia group and sevoflurane based inhalational anesthesia groupTimepoint: The time points for estimation of these parameters are: <br/ ><br>a)at baseline <br/ ><br>b) after temporary clipping if applicable <br/ ><br>c) after permanent clipping <br/ ><br>d) 6 hours after extubation
- Secondary Outcome Measures
Name Time Method The postoperative incidence of delayed cerebral ischemia along with short and long term outcome <br/ ><br>Timepoint: 1)Modified rankin score at discharge, at 6 weeks, and at 12 weeks <br/ ><br>2) Glasgow outcome score at 12 weeks