Effects of acute inflammatory reaction on immunological and psychological parameters in obese people

Not Applicable

Recruiting

Conditions: E66
Obesity

Registration Number: DRKS00009624

Lead Sponsor: Klinik für NephrologieUniversitätsklinikum Essen

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: All

Target Recruitment: 60

Inclusion Criteria

Healthy subjects aged 18-35. People with a Body Mass Index (BMI) of more than 30kg/m2 are assigned to the group of obese subjects; people with a BMI of less than 25kg/m2 are assigned to the group of normal-weight subjects.

Exclusion Criteria

Excessive use pf nicotine and alcohol, known chronical infectious diseases like hepatitis B/C and HIV, known cardiovascular diseases like coronary artery disease, known pneumological diseases like COPD or bronchial asthma, malignant tumors, known autoimmune disorders, other relevant and manifest diseases of internal organs, psychiatric disorders, antidepressant/neuroleptic treatment, antiinflammatory or immunsuppressive treatment and pregnancy.

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
ACTH, cortisol, catecholamines, cytokines (IL-1ra, IL- ß, 1IL-6, IL-10, TNF alpha) and adipokines in plasma are measured before and 1, 2, 3, 4, 6, and 24 hours after the injection.

Secondary Outcome Measures

Name	Time	Method
Before the study psychological parameters are measured by using questionnaires. Questionnaires used: Questionnaire about social support (SOZ-U), Life-Orientation-Test-Revised (LOTR) and neuroticsm-scale of the Neo-personality inventory in the revised version (NEO-PI-R). <br><br>During the study the subjective rating of state is measured 2, 4 and 6 hours after the injection using standardised questionnaires: Beck-Depression-Inventory II (BDI-II), State-Trait-Anxiety-Inventory (STAI), Profile of Mood States (POMS) and Stanford Sleepiness Scale (SSS).<br><br>Moreover, during the study the following physiological parameters are measured: body temepratur, blood pressure, heart rate.<br><br>Additionally, before and 24 hours after the injection, the cognitive parameters reaction time, psychomotoric functioning and inhibitory control are measured by computerized tests (TAP).<br>