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临床试验/NCT00883363
NCT00883363已完成不适用

Reduction of Myocardial Infarction by Preconditioning in Patients With Ruptured Abdominal Aortic Aneurysm

Nikolaj Eldrup1 个研究点 分布在 1 个国家目标入组 200 人开始时间: 2009年4月1日最近更新:
适应症
干预措施

试验速览

阶段
不适用
状态
已完成
发起方
入组人数
200
试验地点
1
主要终点
Reduction in myocardial infarction

研究概览

简要总结

Preconditioning in patients treated for elective abdominal aneurysm showed that the rate of perioperative myocardial infarction could be reduced by 80 %(ARR from 27% to 5%). Precondition where performed by 10 minutes of clamping of each iliac arteries before clamping the abdominal aorta. Human studies in cardiac patients have shown promising results with precondition. Instead of clamping arteries they have all performed the procedure by inflating a blood pressure cuff above arterial pressure on a arm.

The investigators want to investigate if preconditioning induced by a blood pressure cuff on a arm can reduce the perioperative rate of myocardial infarction in patients open operated for ruptured abdominal aortic aneurysm.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Parallel
主要目的
Treatment
盲法
None

入排标准

年龄范围
18 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者
否

入选标准

  • •Patients with ruptured abdominal aortic aneurysm offered surgery
  • •Age > 18 years

排除标准

  • •Technical inoperable

研究组 & 干预措施

Control

No Intervention

No precondition

Precondition

Experimental

Induction of precondition at start of operation on a arm

干预措施: Precondition (Procedure)

结局指标

主要结局

Reduction in myocardial infarction

时间窗: 4 to 5 years

次要结局

  • Improvement in survival Description on inflammatory response(4 to 5 years)

研究者

发起方
Nikolaj Eldrup
申办方类型
Other
责任方
Sponsor Investigator
主要研究者

Nikolaj Eldrup

MD PhD

Aarhus University Hospital

研究点 (1)

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