The EUROpean and Asian Cardiac and Renal Remote Ischemic Pre-conditioning Study : A Prospective, Randomized Control Trial
Overview
- Phase
- Phase 4
- Intervention
- Not specified
- Conditions
- Acute Kidney Injury
- Sponsor
- A.O.U. Città della Salute e della Scienza
- Enrollment
- 1110
- Locations
- 7
- Primary Endpoint
- Incidence of acute kidney injury
- Status
- Completed
- Last Updated
- 11 years ago
Overview
Brief Summary
The purpose of the present study is to determine if remote ischemic preconditioning reduces incidence of acute kidney injury in patients with reduced kidney function undergoing Percutaneous Coronary Intervention.
Detailed Description
Acute kidney injury negatively impacts on prognosis after PCI, and only hydratation have shown to reduce this complication. Remote ischemic preconditioning has been demonstrated to reduce periprocedural MI, while impact on aki remains to be assessed
Investigators
Claudio Moretti
Dottor, Head of the Catch Lab
A.O.U. Città della Salute e della Scienza
Eligibility Criteria
Inclusion Criteria
- •undergoing PCI with stenting for all clinical indications
- •carrying (with) a renal clearance less than 60 mL/min/1.73 m2 and more than 30 mL/min/1.73 m2 (evaluated through MDRD); ù
- •younger than 85 years old.
Exclusion Criteria
- •ST Segment Elevation Myocardial Infarction (STEMI), unstable hemodynamic presentations (cardiogenic shock) or ongoing severe arrhythmias;
Outcomes
Primary Outcomes
Incidence of acute kidney injury
Time Frame: 24 and 48 hours after PCI
Acute Kidney Injury defined as Acute kidney injury is defined as an increase serum creatinine greater than 0.5 mg/dL, or by a relative increase of at least 25% over the baseline value within a period of 48-hours after contrast medium administration
Secondary Outcomes
- Incidence of periprocedural myocardial infarction(24 and 48 hours after PCI)