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Clinical Trials/NCT02149316
NCT02149316
Completed
Not Applicable

Cardioprotective Effects of Remote Ischemic Preconditioning With Postconditioning of the Recipient on Donor Heart in Heart Transplantation Surgery

Chinese Academy of Medical Sciences, Fuwai Hospital1 site in 1 country60 target enrollmentFebruary 2014
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ConditionsMyocardial Ischemic Reperfusion InjuryEnd Stage Heart DiseaseHeart FailureCardiomyopathy

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Myocardial Ischemic Reperfusion Injury
Sponsor
Chinese Academy of Medical Sciences, Fuwai Hospital
Enrollment
60
Locations
1
Primary Endpoint
serum cardiac troponin I (cTnI)
Status
Completed
Last Updated
9 years ago
OverviewInvestigatorsEligibility CriteriaOutcomesSitesSimilar Trials

Overview

Brief Summary

The purpose of this study is to determine whether remote ischemic preconditioning with postconditioning (RIPC+RIPostC) reduces myocardial injury and improves clinical outcomes in heart transplantation surgery.

Registry
clinicaltrials.gov
Start Date
February 2014
End Date
February 2016
Last Updated
9 years ago
Study Type
Interventional
Study Design
Parallel
Sex
All

Investigators

Sponsor
Chinese Academy of Medical Sciences, Fuwai Hospital
Responsible Party
Principal Investigator
Principal Investigator

Guyan Wang

The Chief of Infection-Control Department

Chinese Academy of Medical Sciences, Fuwai Hospital

Eligibility Criteria

Inclusion Criteria

  • •scheduled for elective orthotopic heart transplantation surgery

Exclusion Criteria

  • •peripheral vascular disease affecting the upper arms
  • •mechanical circulatory support before surgery
  • •taking the antidiabetic sulphonylurea, glibenclamide
  • •cold ischemic time of donor heart \> 12 hours
  • •repeated heart surgery

Outcomes

Primary Outcomes

serum cardiac troponin I (cTnI)

Time Frame: within 72 hours after aortic declamping

Secondary Outcomes

  • plasma microRNA-133b (miR-133b)(within 72 hours after aortic declamping)
  • plasma microRNA-208a (miR-208a)(within 72 hours after aortic declamping)

Study Sites (1)

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