Improving oxidant effects following open heart surgery
Not Applicable
- Conditions
- Coronary artery bypass grafting.Presence of aortocoronary bypass graftZ95.1
- Registration Number
- IRCT20201014049022N1
- Lead Sponsor
- Tehran University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 50
Inclusion Criteria
Candidate for coronary artery bypass grafting with cardiopulmonary bypass
Normal upper limb examinations
Not having surgical operations in the past three months
Not having acute medical conditions during the last three months
Exclusion Criteria
Known inflammatory disorders
Diabetes
Liver disease
Kidney disease
Receiving vitamins C and/or E and/or other antioxidants
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Total antioxidant capacity. Timepoint: After anesthesia induction, after cardiopulmonary bypass, 24 hours after intensive care unit admission. Method of measurement: With turbidimetry analysis.;Glutathione peroxidase activity assay. Timepoint: After anesthesia induction, after cardiopulmonary bypass, 24 hours after intensive care unit admission. Method of measurement: With turbidimetry analysis.
- Secondary Outcome Measures
Name Time Method Troponin level. Timepoint: After anesthesia induction, after cardiopulmonary bypass, 24 hours after intensive care unit admission. Method of measurement: ELISA.;Ejection fraction. Timepoint: Every 8 hours after intensive care unit admission. Method of measurement: Echocardiography.