Renal Effects of Remote Ischemic Preconditioning in Patients After Total Arch Replacement
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Acute Kidney Injury
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
- Enrollment
- 130
- Locations
- 1
- Primary Endpoint
- Incidence of AKI within the 7 days after the surgery
- Status
- Completed
- Last Updated
- 7 years ago
Overview
Brief Summary
The purpose of this study is to test the hypothesis that remote ischemic preconditioning prevents acute kidney injury and improves clinical outcomes in patients undergoing total arch replacement.
Detailed Description
Acute kidney injury (AKI) is a well-recognized complication after cardio-thoracic surgeries and is associated with increased morbidity and mortality. Total arch replacement is reported with a relatively high incidence of post-operative AKI. In addition, few effective preventive or therapeutic interventions for AKI have been identified. A number of studies have now addressed renal protection as a primary outcome following RIPC. Because the mechanism of I/R injury are similar to those proposed for AKI after CPB, the purpose of this study is to test the hypothesis that remote ischemic preconditioning prevents acute kidney injury and improves clinical outcomes in patients undergoing total arch replacement.
Investigators
Guyan Wang
The Chief of Infection-Control Department
Chinese Academy of Medical Sciences, Fuwai Hospital
Eligibility Criteria
Inclusion Criteria
- •patients scheduled for total arch replacement
- •written informed consent
Exclusion Criteria
- •pre-existing AKI
- •peripheral vascular disease affecting the upper limbs
- •hybrid total arch replacement
- •the history of kidney transplantation
Outcomes
Primary Outcomes
Incidence of AKI within the 7 days after the surgery
Time Frame: Within 7 days after the surgery
AKI defined by KDIGO criteria
Secondary Outcomes
- Renal replacement therapy(Within 30 days after the surgery)
- Length of intensive care unit stay(Within 30 days after the surgery)
- Incidence of severe AKI (stage 2 and stage 3)(Within 7 days after the surgery)
- In-hospital death(Within 30 days after the surgery)
- Stroke(Within 30 days after the surgery)
- Paraplegia(Within 30 days after the surgery)
- Mechanical ventilation duration(Within 30 days after the surgery)