Renal PRotection Against Contrast mEdium-induced nephroPathy in High Risk Patients undErgoing Coronary Angiography
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Renal Insufficiency
- Sponsor
- University Hospital, Angers
- Enrollment
- 220
- Locations
- 1
- Primary Endpoint
- Increase in serum creatinin level (≥25% or 0,5mg/dL)
- Status
- Completed
- Last Updated
- 7 years ago
Overview
Brief Summary
This study evaluates the efficacy of remote ischemic preconditioning on preventing contrast medium-induced nephropathy in a population of high risk patients undergoing coronary angiography. Half of participants will receive a preconditioning procedure while the other half will receive a sham procedure.
Detailed Description
Contrast medium-induced nephropathy has a big impact on clinical outcomes in patients suffering from renal insufficiency who undergo percutaneous coronary interventions. Remote ischemic preconditioning is proved to protect myocardium in patients undergoing percutaneous coronary angiography. We will evaluate the effect of remote preconditioning on renal protection.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Patient headed to coronary angiography
- •Glomerular filtration rate :
- •≤ 40ml/min/1,73m² (MDRD equation)
- •or ≤ 60ml/min/1,73m² (MDRD equation) with 1 additional risk factor : age \> 75 years, NYHA ≥ III/IV, diabetes mellitus
- •Signed informed consent
Exclusion Criteria
- •Preoperative assessment / dilated cardiomyopathy assessment
- •Acute ST-segment elevation myocardial infarction
- •Cardiogenic shock requiring pressor amine or systolic blood pressure \<80mmHg
- •Resuscitation after cardiac arrest
- •Intra-aortic balloon pump
- •Contraindication for the repeted use of an upper-arm pressure cuff
- •Extra-renal epuration
- •No health insurance coverage
- •Legal incapacity (patients under tutorship, curatorship or judicial protection)
- •Patient enrolled in another interventional trial or being in a washout period
Outcomes
Primary Outcomes
Increase in serum creatinin level (≥25% or 0,5mg/dL)
Time Frame: 48h after coronary angiography
Serum creatinin level is measured 48h after coronary angiography to assess contrast medium-induced nephropathy
Secondary Outcomes
- Serum creatinin level is measured 12 months after coronary angiography and major adverse events are collected to assess long-term effects of remote ischemic preconditioning on renal function(12 months after coronary angiography)