跳至主要内容
临床试验/CTRI/2022/08/045033
CTRI/2022/08/045033尚未招募不适用

Erector spinae plane block for postoperative analgesia following percutaneous nephrolithotomy: A randomized controlled study

M S Ramaiah Medical College1 个研究点 分布在 1 个国家目标入组 88 人开始时间: 2022年1月9日最近更新:

试验速览

阶段
不适用
状态
尚未招募
入组人数
88
试验地点
1
主要终点
Total analgesic requirement in the first 24 hours after surgery

研究概览

简要总结

Percutaneous nephrolithotomy (PCNL) is currently thefrequently employed surgical procedure for the removal of large complex renaland proximal ureteric calculi. Being minimally invasive it hasless morbidity, and allows early recovery and ambulation after surgery. Postoperativepain following PCNL has both visceral and somatic components. Visceralcomponent arises from the kidney, renal capsule and ureter, while the somaticcomponent from the skin incision and the nephrostomy tract. The nephrostomy tube that is inserted at the end of the procedure can elicitinflammatory reaction leading to pain and discomfort.

Although PCNL is a minimally invasive procedure,postoperative pain can be severe and inadequate postoperative analgesia is abarrier to early recovery after surgery. Systemic analgesics like opioids,non-steroidal anti-inflammatory drugs (NSAIDs) and paracetamol form themainstay for providing pain relief. However, opioids are associated with sideeffects like nausea, vomiting, pruritus, constipation, and respiratorydepression, while NSAIDs may be relatively contraindicated in these patientswho may have compromised renal function.

Regional anaesthetic techniques like intercostalnerve block, paravertebral block, epidural analgesia, peritubal infiltrationand subcutaneous infiltration have been employed for providing postoperativeanalgesia following PCNL.Erector spinae plane [ESP] block is arecently described interfascial  planeblock for providing postoperative analgesia following thoracic and abdominalsurgeries.Its use for providing pain relief following PCNL isrecently been described in literature,  However , there is paucityof literature providing its efficacy following PCNL surgery. Hence, the presentstudy is designed to evaluate its role in providing postoperative analgesiafollowing PCNL.

研究设计

研究类型
Interventional
分配方式
Computer generated randomization
盲法
Participant, Investigator and Outcome Assessor Blinded

入排标准

年龄范围
18.00 Year(s) 至 70.00 Year(s)(—)
性别
All

入选标准

  • American Society of Anaesthesiology physical status 1 and 2 Unilateral Percutaneous Nephrolithotomy Surgery.

排除标准

  • BMI ≥ 35kg/m2 Bilateral PCNL Chronic analgesic use Allergy to local anaesthetics Contraindications to ESP block Cognitive dysfunction Pregnancy Spine deformity Relook Percutaneous Nephrolithotomy Surgery.

结局指标

主要结局

Total analgesic requirement in the first 24 hours after surgery

时间窗: Total analgesic dose consumed will be assessed at the end of 24 hours after surgery.

次要结局

  • Postoperative pain(Pain assessed at intervals of 30 minutes, 1 hour, 2 hours, 4 hours, 6 hours, 12 hours and 24 hours after surgery)
  • Time to first demand of rescue analgesia

研究者

申办方类型
Private medical college

研究点 (1)

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