Effect of Various Drugs To Improve Pain Relief After Breast Cancer Surgery

Recruiting

• Conditions: breast cancer

• Registration Number: CTRI/2018/03/012876
• Lead Sponsor: Sri Guru Ram Das Institute Of Medical Sciences And Research

Brief Summary

The aim of this study is to compare the pain relief and complications after epidural administration of ropivacaine or ropivacaine–butorphenol or ropivacaine-fentanyl or complications arising due to the procedure itself, in patients undergoing Modified Radical Mastectomy(MRM). The study will be conducted on 90 females undergoing Modified Radical Mastectomy will be divided into 3 groups with 30 patients each. Group A will be given ropivacaine 0.25% 6ml with 2 ml of normal saline through epidural route; Group B will receive 6ml of 0.25% ropivacaine with butorphanol 1ml (1mg/ml) and 1 ml normal saline through epidural route.; Group C will receive 6ml of 0.25% ropivacaine with 2 ml fentanyl (100 micrograms) through epidural route. The postoperative analgesia will be given as epidural top-ups in the form of ropivacaine(0.125% 6ml) and the data from the above study will be systematically collected, compiled and statistically analyzed to draw relevant conclusions.

Detailed Description

Not available

Study Timeline

• Study Start: 2017-01-31
• Last Update Posted: 2018-01-08

Recruitment & Eligibility

• Status: Open to Recruitment
• Sex: Female
• Target Recruitment: 90

Inclusion Criteria

ASA grade 1 & 2.

Exclusion Criteria

• Patients having bleeding diathesis 2.
• Patients on any anticoagulant therapy 3.
• Patients with known hypersensitivity to local anaesthetics or study drugs.
• Patient suffering from uncontrolled asthma, cardiac, respiratory, renal, thyroid, hepatic and CNS disorders.
• Patients with local sepsis or spinal deformity.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Duration Of Postoperative Analgesia	Duration Of Analgesia From Drug Administration To VAS Equals To Or More Than 4 in Postoperative Period In First 24 Hours

Secondary Outcome Measures

Name	Time	Method
1.Intraoperative Haemodyanamic Stability	2.Total Dose Of Postoperative Analgesic Requirement

Trial Locations

Locations (1)

Sri Guru Ram Das Institute Of Medical Sciences And Research; 🇮🇳 Amritsar, PUNJAB, India

Sri Guru Ram Das Institute Of Medical Sciences And Research

🇮🇳Amritsar, PUNJAB, India

Dr Ruchi Gupta

Principal investigator

9814320805

drruchisgrd@gmail.com