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Clinical Trials/NCT06301932
NCT06301932
Completed
N/A

The Effectiveness and Outcomes of Epidural Analgesia in Patients Undergoing Open Hepatectomy: A Propensity Score Matching Analysis

Chiang Mai University0 sites654 target enrollmentJanuary 1, 2006

Overview

Phase
N/A
Intervention
Not specified
Conditions
Epidural Analgesia
Sponsor
Chiang Mai University
Enrollment
654
Primary Endpoint
Post-operative opioid consumption
Status
Completed
Last Updated
2 years ago

Overview

Brief Summary

This observational study is to compare the effectiveness and outcomes of epidural analgesia in patients undergoing open hepatectomy: A propensity score matching analysis.

The main question is: What is the superior method of pain control in open hepatectomy: epidural analgesia or intravenous PCA?

Detailed Description

After approval of the study protocol from the institutional review board of Chiangmai University (Approval number: ANE-2562-06771), the investigators performed a retrospective review of all patients who underwent an elective open liver resection in the specialized hepato-biliary center from January 2007 through December 2018. This retrospective inquiry comprised 612 patients. The data was systematically retrieved from electronic medical records. Baseline characteristics including age, gender, body mass index (BMI), co-morbidity, American Society of Anesthesiologists (ASA) classification, diagnosis, hepatitis profile, Child-Pugh classification, cirrhosis, the largest tumor size, previous liver resection, and pre-operative laboratory investigations were collected. The following intra-operative data were collected: type of liver resection, hilar resection, vascular reconstruction, intra-operative opioid consumption and type of fluid administration, estimated blood loss, packed red cell and blood product transfusion, and operation time. Post-operative pain score and opioid consumption also be collected.

Registry
clinicaltrials.gov
Start Date
January 1, 2006
End Date
December 31, 2023
Last Updated
2 years ago
Study Type
Observational
Sex
All

Investigators

Responsible Party
Principal Investigator
Principal Investigator

Isarapong Pianngarn

Principal Investigator

Chiang Mai University

Eligibility Criteria

Inclusion Criteria

  • All gender age above 18 years old
  • Undergoing open liver resection surgery

Exclusion Criteria

  • No documentation of the numerical rating scale (NRS)
  • Epidural failure

Outcomes

Primary Outcomes

Post-operative opioid consumption

Time Frame: Within 72 hours

Post-operative opioid consumption at 24,48,72 hour

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