The Effectiveness and Outcomes of Epidural Analgesia in Patients Undergoing Open Hepatectomy

Completed

• Conditions: Patient Controlled Analgesia; Epidural Analgesia
• Interventions: Procedure: Open liver resection

• Registration Number: NCT06301932
• Lead Sponsor: Chiang Mai University

Brief Summary

This observational study is to compare the effectiveness and outcomes of epidural analgesia in patients undergoing open hepatectomy: A propensity score matching analysis.

The main question is: What is the superior method of pain control in open hepatectomy: epidural analgesia or intravenous PCA?

Detailed Description

After approval of the study protocol from the institutional review board of Chiangmai University (Approval number: ANE-2562-06771), the investigators performed a retrospective review of all patients who underwent an elective open liver resection in the specialized hepato-biliary center from January 2007 through December 2018. This retrospective inquiry comprised 612 patients. The data was systematically retrieved from electronic medical records. Baseline characteristics including age, gender, body mass index (BMI), co-morbidity, American Society of Anesthesiologists (ASA) classification, diagnosis, hepatitis profile, Child-Pugh classification, cirrhosis, the largest tumor size, previous liver resection, and pre-operative laboratory investigations were collected. The following intra-operative data were collected: type of liver resection, hilar resection, vascular reconstruction, intra-operative opioid consumption and type of fluid administration, estimated blood loss, packed red cell and blood product transfusion, and operation time. Post-operative pain score and opioid consumption also be collected.

Study Timeline

• Study Start: 2006-01-01
• Primary Completion: 2018-12-31
• Study Completion: 2023-12-31
• Status Verified: 2024-03
• Study First Submitted: 2024-03-04
• Study First Submitted QC: 2024-03-04
• Last Update Submitted: 2024-03-07
• Study First Posted: 2024-03-08
• Last Update Posted: 2024-03-12

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 654

Inclusion Criteria

• All gender age above 18 years old
• Undergoing open liver resection surgery

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Exclusion Criteria

• No documentation of the numerical rating scale (NRS)
• Epidural failure

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Epidural analgesia	Open liver resection	Group of the patients received epidural analgesia
Non epidural analgesia	Open liver resection	Group of the patients who did not received epidural analgesia

Primary Outcome Measures

Name	Time	Method
Post-operative opioid consumption	Within 72 hours	Post-operative opioid consumption at 24,48,72 hour