Outdoor Allergen Exposure, Sensitivity, and Acute Asthma

Completed

• Conditions: Asthma

• Registration Number: NCT00043992
• Lead Sponsor: National Institute of Environmental Health Sciences (NIEHS)

Brief Summary

To examine the role of outdoor pollen grains and fungal spores in the exacerbation of asthma and to produce forecasting models to predict days of high concentration.

Detailed Description

Asthma is a growing problem, and outdoor allergens play a role in exacerbation of many cases. A clearer understanding of this role and its magnitude, and a means of controlling the effects of outdoor allergen exposures is needed. We propose Poisson time-series and conditional panel studies to test these hypotheses: 1) The incidence of acute asthma attacks, as measured by urgent care inhalation treatments and hospitalizations for asthma, has a dose-dependent relationship with exposure to specific outdoor allergens; 2) Specific sensitization to outdoor allergens is a risk factor for having an acute attack; and 3) Exposure conditions that lead to acute asthma attacks can be forecast, creating an opportunity to reduce asthma morbidity and mortality ny targeting pretreatment and/or exposure controls.

Study Timeline

• Study Start: 2001-07
• Study First Submitted: 2002-08-16
• Study First Submitted QC: 2002-08-16
• Study First Posted: 2002-08-19
• Status Verified: 2006-09
• Last Update Submitted: 2006-09-01
• Last Update Posted: 2006-09-04

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 1000

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Trial Locations

Locations (1)

Fallon Clinic and Fallon Community Health Plan; 🇺🇸 Worcester, Massachusetts, United States