A Combined Training Program for Veterans With Amnestic Mild Cognitive Impairment

Not Applicable

Completed

• Conditions: Amnestic Mild Cognitive Impairment
• Interventions: Behavioral: Combined Aerobic and Resistance Exercise; Behavioral: Stretching Exercises; Behavioral: Cognitive Training

• Registration Number: NCT01962038
• Lead Sponsor: Palo Alto Veterans Institute for Research

Brief Summary

The purpose of this study is examine the efficacy of a combination physical exercise and cognitive training program on improving memory in older Veterans with amnestic Mild Cognitive Impairment.

Detailed Description

Not available

Study Timeline

• Study Start: 2013-05
• Study First Submitted: 2013-08-26
• Study First Submitted QC: 2013-10-09
• Study First Posted: 2013-10-14
• Primary Completion: 2017-07
• Study Completion: 2017-11
• Status Verified: 2018-04
• Last Update Submitted: 2018-04-03
• Last Update Posted: 2018-04-05

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 72

Inclusion Criteria

• diagnosis of amnestic Mild Cognitive Impairment
• available informant
• visual and auditory acuity to allow neuropsychological testing
• willingness to participate in exercise training + cognitive training for 8 months
• approval of primary provider to participate in exercise trial

Exclusion Criteria

• current severe psychiatric disorder
• diagnosis of dementia
• history of neurological or system illness affecting CNS function
• acute illness or unstable chronic illness
• current severe cardiac disease
• inability to exercise consistently because of orthopedic or musculoskeletal problems
• morbid obesity
• inability to read, verbalize understanding and voluntarily sign the informed consent

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Stretching Exercises/Cognitive Training	Cognitive Training	-
Combined Aerobic and Resistance Exercise/Cognitive Training	Combined Aerobic and Resistance Exercise	-
Combined Aerobic and Resistance Exercise/Cognitive Training	Cognitive Training	-
Stretching Exercises/Cognitive Training	Stretching Exercises	-

Primary Outcome Measures

Name	Time	Method
Change from Baseline to 28 weeks in delayed recall of a word list	Baseline, 24 weeks, 28 weeks
Change from Baseline to 28 weeks in Delayed Recall of Names-Face Task	Baseline, 24 weeks, 28 weeks

Secondary Outcome Measures

Name	Time	Method
Non-Cognitive Outcomes (Depression, Sleep, Quality of Life)	Baseline, Time 2, Time 3

Trial Locations

Locations (1)

VA Palo Alto Health Care System; 🇺🇸 Palo Alto, California, United States