A Combined Training Program for Veterans With Amnestic Mild Cognitive Impairment
Not Applicable
Completed
- Conditions
- Amnestic Mild Cognitive Impairment
- Registration Number
- NCT01962038
- Lead Sponsor
- Palo Alto Veterans Institute for Research
- Brief Summary
The purpose of this study is examine the efficacy of a combination physical exercise and cognitive training program on improving memory in older Veterans with amnestic Mild Cognitive Impairment.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 72
Inclusion Criteria
- diagnosis of amnestic Mild Cognitive Impairment
- available informant
- visual and auditory acuity to allow neuropsychological testing
- willingness to participate in exercise training + cognitive training for 8 months
- approval of primary provider to participate in exercise trial
Exclusion Criteria
- current severe psychiatric disorder
- diagnosis of dementia
- history of neurological or system illness affecting CNS function
- acute illness or unstable chronic illness
- current severe cardiac disease
- inability to exercise consistently because of orthopedic or musculoskeletal problems
- morbid obesity
- inability to read, verbalize understanding and voluntarily sign the informed consent
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method Change from Baseline to 28 weeks in delayed recall of a word list Baseline, 24 weeks, 28 weeks Change from Baseline to 28 weeks in Delayed Recall of Names-Face Task Baseline, 24 weeks, 28 weeks
- Secondary Outcome Measures
Name Time Method Non-Cognitive Outcomes (Depression, Sleep, Quality of Life) Baseline, Time 2, Time 3
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What molecular mechanisms (e.g., BDNF, synaptic plasticity) underlie combined exercise and cognitive training in amnestic mild cognitive impairment (aMCI)?
How does multimodal behavioral intervention compare to standard-of-care pharmacological therapies for aMCI in veterans?
Which biomarkers (e.g., hippocampal volume, amyloid-beta levels) predict response to combined aerobic/resistance exercise and cognitive training in aMCI?
What adverse events (e.g., musculoskeletal injury, cognitive fatigue) are associated with combined exercise and cognitive training in aMCI populations?
What non-pharmacological combination therapies (e.g., Tai Chi, spaced retrieval) synergize with physical exercise for aMCI treatment?
Trial Locations
- Locations (1)
VA Palo Alto Health Care System
🇺🇸Palo Alto, California, United States
VA Palo Alto Health Care System🇺🇸Palo Alto, California, United States