A Combined Exercise Program Plus Cognitive Training for Older Adults With Self-reported Cognitive Complaints: The Multi-modal, Mind-motor (M4) Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 127
- 试验地点
- 2
- 主要终点
- Composite score from Cambridge Brain Sciences Cognitive Battery - 12 tasks
研究概览
简要总结
The purpose of this study is to investigate whether an exercise class with a cognitive (or brain) training component was more effective than a usual combined aerobic and resistance exercise class for older adults with cognitive complaints (such as concerns about changes in memory or thinking skills). It is hypothesized that the group randomized to the exercise class that includes additional brain training will have greater improvements in brain health.
详细描述
Older adults with self-reported cognitive complaints (CCs) may be at increased risk for the development of Alzheimer's disease and dementia. Cognitive decline in older adults, particularly reduced memory and executive function is associated with functional decline, institutionalization, and increased health care costs. Similarly, cardiovascular risk factors have been associated with cognitive and functional impairment in aging. Aerobic exercise has been shown to improve vascular function and blood flow in the brain's prefrontal cortex. In turn, resistance training can produce functional changes within distinct cortical regions during the encoding and recall of association tasks and has been shown to increase circulating neural growth factors (i.e., a proposed mechanism by which cognition may be preserved or improved in old age). Recent evidence also suggests that cognitive training may improve the cognitive performance of older adults.
Therefore, we will investigate the impact of a combined exercise program (multi-modality exercise; M2) compared to a combined exercise program with a cognitive component (multi-modality, mind-motor exercise; M4) on cognition, cognitive-motor, mobility, neural functioning and vascular outcomes in older adults with cognitive complaints. Community-based exercise programs for older adults provide widespread access, are relatively inexpensive, and provide opportunities for social interaction.
The primary purpose of this study is to compare the effects of the M2 and M4 exercise programs on brain health. This study will also examine the effects of the different exercise programs on cardiovascular risk factors and mobility. In a subset of participants, cognitive-motor and neural functioning outcomes will be examined.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 55 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •aged 55 years or older
- •self-reported cognitive complaint (defined as answering yes to the question "Do you feel like your memory or thinking skills have gotten worse recently?).
- •independent on instrumental activities of daily living
排除标准
- •Probable Dementia (i.e., diagnosis OR Mini-Mental State Examination score <24)
- •Other neurological conditions or major psychiatric disorders (i.e., Parkinson's disease; bipolar disorder)
- •Previous history of severe cardiovascular conditions (i.e., myocardial infarction or stroke <1-year ago; end stage congestive heart failure; end stage renal disease)
- •Severe sensory impairment (i.e., blind)
- •Significant orthopedic conditions (i.e., severe osteoarthritis)
- •Clinical depression (determined via >=16 on the Center for Epidemiologic Studies - Depression Scale AND review by primary study physician)
- •Have blood pressure >180/100 mmHg or <100/60 mmHg
- •Unable to comprehend questionnaire material
- •Any other factors that could potentially limit ability to fully participate in the intervention
结局指标
主要结局
Composite score from Cambridge Brain Sciences Cognitive Battery - 12 tasks
时间窗: 6 months
To assess global cognitive function
次要结局
- Composite score from Cambridge Brain Sciences Cognitive Battery - 12 tasks(12 months)
- Gait variability (stride time) under dual-task conditions(6 & 12 months)
- Gait velocity (speed) under dual-task conditions(6 & 12 months)
- Gait velocity (speed) under single-task conditions(6 & 12 months)
- Step length (average) under dual-task conditions(6 & 12 months)
- Composite score of executive function tasks from Cambridge Brain Sciences Cognitive Battery(6 & 12 months)
- Gait variability (stride time) under single-task conditions(6 & 12 months)
- Clinic Diastolic Blood Pressure(6 & 12 months)
- Step length (average) under single-task conditions(6 & 12 months)
- Carotid Artery Compliance(6 & 12 months)
- Carotid Artery Intima-media thickness(6 & 12 months)
- Ambulatory Systolic Blood Pressure(6 & 12 months)
- Composite score of concentration tasks from Cambridge Brain Sciences Cognitive Battery(6 & 12 months)
- Clinic Systolic Blood Pressure(6 & 12 months)
- Ambulatory Diastolic Blood Pressure(6 & 12 months)
- Total balance score(6 & 12 months)
- Composite score of memory tasks from Cambridge Brain Sciences Cognitive Battery(6 & 12 months)
研究者
Rob Petrella
Principal Investigator
Lawson Health Research Institute