Effects of Exercise and Cognitive Training on Cognitive Function in Older Adults

Not Applicable

Completed

• Conditions: Aging; Alzheimer's Disease

• Registration Number: NCT01038726
• Lead Sponsor: The Cleveland Clinic

Brief Summary

The purpose of this study is to gain a better understanding of the effects of exercise and cognitive training on improving brain function in healthy older adults who may be at risk for developing Alzheimer's Disease.

Detailed Description

Not available

Study Timeline

• Study Start: 2009-12
• Study First Submitted: 2009-12-21
• Study First Submitted QC: 2009-12-22
• Study First Posted: 2009-12-24
• Primary Completion: 2012-09
• Study Completion: 2012-09
• Status Verified: 2013-09
• Last Update Submitted: 2013-09-17
• Last Update Posted: 2013-09-18

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 108

Inclusion Criteria

• First or Second-degree relative of someone with Alzheimer's Disease
• Not currently engaging in regular exercise
• Able to undergo an MRI
• Fluent in English

Exclusion Criteria

• Neurological illnesses/conditions
• Medical illness/conditions that may affect brain function
• Any unstable or severe cardiovascular disease or asthmatic condition
• Severe depressive symptoms
• Inability to walk unassisted

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Brain activation patterns measured by functional MRI	baseline and 12 weeks

Secondary Outcome Measures

Name	Time	Method
Neuropsychological Testing	baseline and 12 weeks
Exercise assessment	baseline and 12 weeks

Trial Locations

Locations (1)

The Cleveland Clinic; 🇺🇸 Cleveland, Ohio, United States