Influence of Physical Exercise on Cognitive Functioning of Traumatic Brain Injury Patients
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Brain Injuries
- Sponsor
- Federal University of São Paulo
- Enrollment
- 36
- Locations
- 1
- Primary Endpoint
- Neuropsychological evaluation
- Last Updated
- 14 years ago
Overview
Brief Summary
The aim of this study is to determine the effects of an acute session of physical exercise on cognitive functioning and humor of traumatic brain injury patients and to investigate whether different cognitive responses can be achieved with different intensities of exercise (moderate and vigorous).
The investigators hypothesize that while moderate intensity physical exercise may be beneficial to cognitive functioning, vigorous intensity may be detrimental to TBI patients, as physical fatigue may impair alertness and other higher cognitive functions.
Detailed Description
It is well known the benefits of physical exercise to cognitive functioning, which have been demonstrated in animal studies and in those with healthy humans or with individuals with some type of pathology. Nevertheless, there are few studies investigating the effects of acute physical exercise on cognitive functions of people with traumatic brain injury, even though they frequently have impairments in several cognitive domains due to their brain damage. The effect of two intensities of physical exercise (moderate and exhaustive) in attention, processing speed, memory, executive control and decision making will be investigated in patients with TBI. For that matter, their performance will be compared to non-brain injured subjects submitted to the same protocol and to TBI patients submitted to a stretching session. Each subject will be submitted to a neuropsychological evaluation before and after the physical exercise in order to determine if there is an improvement in cognitive performance post-exercise.
Investigators
Eligibility Criteria
Inclusion Criteria
- •diagnose of moderate to severe TBI
- •be at least six-months post-injury
- •have a neurologist that allowed to enroll into the study
- •be able to take part in a cycloergometer-protocol, attested by the laboratory (CEPE) physician
- •brain injury must have occurred in adult life
- •provided written informed consent for participation
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
Neuropsychological evaluation
Time Frame: 1 Day
Neuropsychological evaluation will be held immediately before the execution of physical exercise (maximal, 30 minutes in ventilatory threshold I or stretching exercise) and immediately after the conclusion of exercise.
Secondary Outcomes
- Mood, fatigue and impulsivity questionnaires(1 day)