Acute Exercise on Neurocognitive Function Among Adults With/Without Generic Risk of AD

Not Applicable

Completed

• Conditions: Alzheimer Disease 2 Due to Apoe4 Isoform
• Interventions: Behavioral: LI-40; Behavioral: MI-30; Behavioral: HI-16

• Registration Number: NCT05591313
• Lead Sponsor: National Taiwan Normal University

Brief Summary

This study explores the acute exercise effect on neurocognitive function and also its potential moderators in an exercise setting and Apolipoprotein E (APOE) genetic risk.

Detailed Description

Acute exercise has emerged as a modifier to multiple aspects of cognitive function; however, its effect on populations with different risks of Alzheimer's disease (AD) and the role of exercise variance and APOE genotype within the effect reminds underestimated. The current study aimed to examine the acute exercise effect on neurocognitive function from behavioral and neuroelectric perspectives among cognitively normal late-middle-aged adults. Additionally, we determined whether variations in exercise intensity and duration and the presence of the APOE ɛ4 allele modulated the effect.

Study Timeline

• Study Start: 2016-05-17
• Primary Completion: 2019-09-26
• Study Completion: 2019-09-26
• Study First Submitted: 2022-10-12
• Study First Submitted QC: 2022-10-19
• Study First Posted: 2022-10-24
• Status Verified: 2023-02
• Last Update Submitted: 2023-02-04
• Last Update Posted: 2023-02-08

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 51

Inclusion Criteria

1. Adults aged between 50 and 70 years old
2. Normal or corrected-to-normal vision based on the minimal 20/20 standard
3. Cognitively normal as mini-mental state examination scores (MMSE) > 26

Exclusion Criteria

1. Neurological or psychiatric disorders
2. Cardiovascular disease
3. Risk of cardiovascular fitness assessment based on the Physical Activity Readiness Questionnaire (PAR-Q)
4. Red-green color blindness.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: FACTORIAL

Arm && Interventions

Group	Intervention	Description
Low-intensity with longer duration (40-min) exercise (LI-40)	LI-40	The participants were instructed to complete a volume-matched low-intensity with longer duration (40-min) exercise (LI-40) treatment.
Moderate-intensity with 30 min exercise (MI-30)	MI-30	The participants were instructed to complete a volume-matched moderate-intensity with 30 min exercise (MI-30) treatment.
High-intensity with shorter duration (16-min) exercise (HI-16)	HI-16	The participants were instructed to complete a volume-matched high-intensity with shorter duration (16-min) exercise (HI-16) treatment.

Primary Outcome Measures

Name	Time	Method
Stroop task: Accuracy	Participants were required to complete the Stroop task approximately 30 min following the cessation of each acute exercise treatment or the 30-min reading.	A computerized Stroop task was used to assess participants' inhibitory control and basic information processing. The accuracy was calculated for the second behavioral index.
Event-related potential: P3 amplitude	Participants were required to complete the Stroop task while EEG activity was continuously recorded approximately 30 min following the cessation of each acute exercise treatment or the 30-min reading.	The event-related potential from parietal electrodes (i.e., P3, Pz, and P4) were initially outputted for the mean P3 amplitude; the averaged mean P3 amplitudes from parietal electrodes was then calculated as the neuroelectrical indices.
Stroop task: Response time	Participants were required to complete the Stroop task approximately 30 min following the cessation of each acute exercise treatment or the 30-min reading.	A computerized Stroop task was used to assess participants' inhibitory control and basic information processing. The response time of the correct responses was calculated for the first behavioral index.

Trial Locations

Locations (1)

Department of Physical Education and Sport Sciences, National Taiwan Normal University; 🇨🇳 Taipei, Taiwan